Toxicity and Cosmetic Outcome of Ultrahypofractionation Breast Radiotherapy: Predictive Clinical Factors | ||||
| SVU-International Journal of Medical Sciences | ||||
| Volume 7, Issue 2, July 2024, Page 156-168 PDF (252.35 K) | ||||
| Document Type: Original research articles | ||||
| DOI: 10.21608/svuijm.2022.181801.1477 | ||||
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| Authors | ||||
Asmaa Salah; Mostafa Abdelwanis; Tamer M. Samy  ; Shaimaa Ahmed
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| Radiation Oncology Department, South Egypt Cancer Institute (SECI), Assiut University, Assiut, Egypt. | ||||
| Abstract | ||||
| Background: The current gold standard for adjuvant radiotherapy for breast cancer in nowadays is hypofractionated radiotherapy. Objectives: Here, we discuss early, late, and cosmetic results of 1 week adjuvant breast radiotherapy and to find the predicted indicators for toxicity . Patients and methods: The study included 63 breast cancer patients. Invasive breast cancer patients who undergone mastectomy or breast conserving surgery (pT1-3, pN0-1, M0), were eligible if they were at least 18 years old. Patients got 26 Gy/5F/1-week. Individuals who underwent breast conservation and are younger than 50 years old may employ a sequential boost (dosage of 5.2 Gy/ 1 fraction). After radiation, physician-rated early and late toxicity as well as the cosmetic result were prospectively evaluated. Results: 63 patient assessed early after 6 weeks from end of radiotherapy for acute skin toxicity with grade 2 was 27 % with univariate analysis show no significant association between occurrence of acute toxicity and different factors and after median follow up 25 months , the late toxicity assessment show that moderate & marked radiotherapy related fibrosis represent 6.3%, Telangiectasia(3.2%) and hyperpigmentation(6.3%) with univariate analysis show no significant association between occurrence of late toxicity and different factors. The rate of fair or poor cosmesis was 12.7%, univariate analysis of cosmetic outcome revealed only significant association between cosmosis and chemotherapy . Conclusion: The findings support the viability and safety of 26 Gy in five fractions radiotherapy over 1 week in adjuvant setting in early breast cancer. | ||||
| Keywords | ||||
| Breast cancer; Ultrahypofractionation; Radiotherapy | ||||
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