Fasting Triglycerides and Glucose (TyG index) and Systemic Lupus Erythematosus Disease Activity Score (SLEDAS). | ||||
| Zagazig University Medical Journal | ||||
| Volume 30, Issue 5, August 2024, Page 1671-1678 PDF (964.08 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2024.289316.3396 | ||||
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| Authors | ||||
Dalia I Moatafa1; Amina M. Hosseny 2; Noha A. Abdelsalam3; Mahmoud A. Sharafeddin4; Mona Rabie  3
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| 1Department of Rheumatology, Rehabilitation and Physical Medicine, Faculty of Medicine, Zagazig University, Egypt | ||||
| 2Rheumatology and Rehabilitation and physical medicine, faculty of medicine, Zagazig university,Zagazig, Egypt | ||||
| 3Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||||
| 4Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt | ||||
| Abstract | ||||
| Background: Dyslipidemia is a common drawback in systemic lupus erythematosus (SLE) patients; it is also related to disease activity. Fasting triglycerides and glucose (TyG index) was originally employed as a substitute for measuring insulin resistance (IR), we hypothesized that the TyG index may be an indicator of disease activity. Method: In this study, 87 SLE patients participated. Their demographic, clinical, and laboratory data were assessed. Patients were split into two groups based on the Low Lupus Disease Activity State (LLDAS). Factors correlated with activity were entered in regression analysis with the TyG index. Results: A statistically significant relation was detected between the TyG index and disease activity. There was a significant positive correlation between SLE-DAS & all of the TyG index (r=0.267, p=0.012), ESR (r=0.338, p=0.001), Fasting blood glucose (r=0.268, p=0.012), TGs (r=0.232, p=0.031) and LDL cholesterol (r=0.213, p=0.048). TyG index (unstandardized β=20.425, p=0.028) was significantly and independently associated with disease activity. However, the TyG index revealed a sensitivity of 71.8% but a specificity of 47.2% for identifying high disease activity among SLE patients. Conclusion: A statistically significant positive correlation is detected between SLEDAS and TyG index. Although the TyG index is sensitive but not specific for the detection of high disease activity in SLE patients, it is still not valid and needs further research. | ||||
| Keywords | ||||
| Systemic lupus erythematosus (SLE); TyG index; disease activity; SLE Disease Activity Score (SLEDAS) | ||||
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