A C-634-G Polymorphism of the Interleukin-6 Gene Promoter as a Possible Risk for Idiopathic Recurrent Miscarriage | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 21, Volume 31, Issue 2, June 2011, Page 277-286 PDF (179.47 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2011.36147 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Ayatallah Nassef* 1; Dina Bahgat1; Fouad AboHamila2 | ||||
| 1Clinical and Chemical Pathology Dept., Faculty of Medicine, Cairo University | ||||
| 2Obstetric and Gynecology Dept., Faculty of Medicine, Cairo University | ||||
| Abstract | ||||
| Background: Cytokines have been described to play a major role in the pathogenesis of idiopathic recurrent miscarriage (IRM). We investigated the association between IRM and a polymorphism of the interleukin-6 (IL-6). Methods: In a prospective casecontrol study, we studied 100 women with IRM and 60 healthy controls. Peripheral venous blood sample was taken from each woman for DNA extraction and PCR was employed to genotype women for the presence of a polymorphism at position -634 in the promoter region of IL-6. Results: Allele frequencies among women with IRM and controls were 82.5 and 78.3% respectively for allele C (wild type); 17.5% and 21.6% respectively for allele G (mutant). No association between allele G and the occurrence of IRM was found (odds ratio 1.304; 95% confidence interval = 0.760– 2.299; P= NS). Conclusion: To our knowledge this is the first report on IL-6 polymorphism in IRM on Egyptian population, yet. the IL-6 polymorphism investigated was not associated with IRM in the studied group of Egyptian population. | ||||
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