Antimullerian Hormone Levels in Premenopausal Systemic lupus Erythematosus Patients
kandil, I., Elgawish, M., Esh, A., Hammad, M. (2020). Antimullerian Hormone Levels in Premenopausal Systemic lupus Erythematosus Patients. EKB Journal Management System, 26(3), 510-516. doi: 10.21608/zumj.2019.12936.1230
iman kandil; Mohammad Elgawish; Asmaa Esh; Marwa Hammad. "Antimullerian Hormone Levels in Premenopausal Systemic lupus Erythematosus Patients". EKB Journal Management System, 26, 3, 2020, 510-516. doi: 10.21608/zumj.2019.12936.1230
kandil, I., Elgawish, M., Esh, A., Hammad, M. (2020). 'Antimullerian Hormone Levels in Premenopausal Systemic lupus Erythematosus Patients', EKB Journal Management System, 26(3), pp. 510-516. doi: 10.21608/zumj.2019.12936.1230
kandil, I., Elgawish, M., Esh, A., Hammad, M. Antimullerian Hormone Levels in Premenopausal Systemic lupus Erythematosus Patients. EKB Journal Management System, 2020; 26(3): 510-516. doi: 10.21608/zumj.2019.12936.1230

Antimullerian Hormone Levels in Premenopausal Systemic lupus Erythematosus Patients

Zagazig University Medical Journal
Article 18, Volume 26, Issue 3, May 2020, Page 510-516  XML PDF (880.92 K)
Document Type: Original Article
DOI: 10.21608/zumj.2019.12936.1230
View on SCiNiTO View on SCiNiTO
Authors
iman kandil email 1; Mohammad Elgawish2; Asmaa Esh3; Marwa Hammadorcid 4
1rheumatotlogy and rehabilitation departement,zagagzig university hospitals
2Rheumatology and Rehabilitation Departement,Faculty of medicine,Zagazig University,Egypt
3Clinical Pathology Departement,Faculty of medicine,Zagazig University,Egypt
4Rheumatology and Rehabilitation Faculty of medicine
Abstract
Background: The use of antimullerian hormone (AMH) as a marker of ovarian reserve may contribute to treatment decisions regarding the use of medications with known gonadotoxic effects. This study aimed to assess ovarian reserve by measuring AMH level in premenopausal SLE patients. Subjects and methods: A case control study, included 60 female subjects (30 SLE patients and 30 apparently healthy subjects). Full history taking and examination were carried out in Rheumatology and Rehabilitation Department. Laboratory investigations were conducted in Clinical Pathology Department, Faculty of Medicine, Zagazig University Hospitals. Antimullerian hormone level was measured in both patients and controls. Results: The study included 30 SLE female patients whose ages ranged from 19-50 years with a mean of 32.23 ± 8.846 years. The control group composed of 30 healthy female volunteers, whose ages ranged from 18 - 42 years and a mean of 29.03 ± 7.837 years. The mean of the disease duration was 6.87 ± 4.313 years. The study showed that the median of AMH level in SLE group was 2.7 (0.1-9.7) vs. 3.07 (0.3 – 20) in the control group, p value = 0.146 (P>0.05), therefore there was no statistically significant difference between both groups regarding AMH levels or between serum AMH and different drug use. Conclusion: AMH did not differ between SLE patients and controls & was not affected by the disease duration or activity. Moreover, immunosuppressive agents such as cyclophosphamide, azathioprine and mycophenolate mofetil did not significantly affect the AMH levels in SLE patients.
Keywords
Systemic lupus erythromatosus; Antimullerian hormone; fertility
Statistics
Article View: 290
PDF Download: 262