Effect of Histidine on Autotaxin Activity in Experimentally Induced Liver Fibrosis | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 7, Volume 30, Issue 1, December 2010, Page 123-136 PDF (221.57 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2010.36168 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Manal El-Batch* ; Wafaa Ibrahim; Soha Said | ||||
| Medical Biochemistry Department, Faculty of Medicine, Tanta University | ||||
| Abstract | ||||
| The aim of the present study was to explain whether serum autotaxin activity might be a target for regulation of liver fibrosis and to evaluate the hepato-protective and antifibrotic effects of histidine in thioacetamide induced liver fibrosis in rats. The study was carried out on 100 albino rats, classified into 5 groups each of 20 rats: group І (control group), group ІІ: rats were given histidine intra-peritoneally, group ІІІ: rats were injected intra-peritoneally with thioacetamide, group IV: rats were injected with L-histidine together with thioacetamide, group V: rats were injected with TAA for one month then treated with intra-peritoneal injection of L-histidine for another month. At the end of experiment, blood and liver were collected for determination of some liver enzymes, plasma total antioxidant capacity, serum autotaxin activity and liver tissue hydroxyproline. Thioacetamide treatment caused significant increases in liver enzymes, autotaxin activities and liver hydroxyproline, but with a significant decrease in plasma total antioxidant capacity. Upon treatment with histidine significant decreases in liver enzymes, autotaxin activities and liver hydroxyproline were observed with a significant increase in plasma total antioxidant capacity in group IV and significant decrease in group V. Conclusion: histidine as an antioxidant has a protective effect on thioacetamide-induced liver fibrosis , its beneficial effects in rats might be not only by inhibition of collagen synthesis and increasing total antioxidant capacity, but also by inhibition of autotaxin activities, thus reducing its capacity to produce lysophosphatidic acid which has a role in liver fibrosis. | ||||
| Keywords | ||||
| autotaxin; histidine; Liver fibrosis; Thioacetamide; total anti-oxidant capacity | ||||
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