Comparison of the Efficacy of High Flux versus Low Flux membranes in Chronic Hemodialysis children | ||||
| Zagazig University Medical Journal | ||||
| Volume 30, Issue 6, September 2024, Page 2616-2622 PDF (888.81 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2024.293982.3419 | ||||
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| Authors | ||||
Seham Mohammed Ibrahim Ramadan1; Mohammed Mohammed Abdelsalam Gomaa1; Basma Elsadek Abdelnaby Elsadek  2; Ahmad Mokhtar Ahmad Ibrahem 3; Salma Ahmed Watfa1
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| 1Pediatrics Department, Faculty of Medicine, Zagazig University, Egypt | ||||
| 2Pediatrics Department, Faculty of Medicine – Zagazig University | ||||
| 3Clinical Pathology Department, Faculty of Medicine, Zagazig University, Egypt | ||||
| Abstract | ||||
| Background: adequacy of dialysis is very important and has a major impact on morbidity as well as mortality among hemodialysis (HD) children. Many researchers have reported that high flux membrane (HFM) enhances the medium-sized molecules removal while other reports revealed no remarkable effect on them. This study aimed to compare the efficacy of high-flux hemodialysis (HFHD) versus low-flux hemodialysis (LFHD) in HD children. Patients and methods: In the period from June to December 2023, 50 cases on regular HD for end-stage renal disease included in this retrospective cohort study at the Pediatric nephrology unit, Zagazig University Children's Hospital. Blood samples were collected pre- and post-dialysis and forwarded to the lab for analysis. To evaluate dialysis effectiveness, we employed KT/V, blood urea nitrogen (BUN), as well as urea reduction ratio (URR) parameters. Results: Post dialysis, a significant difference between the groups concerning the adequacy of HD was found according to URR and KT/V(p<0.001, p=0.008 respectively). According to having URR (≥65%), 56% within HF group versus 24% had adequate HD. While according to KT/V (≥1.2), 72% versus 20% within HFHD and LFHD groups respectively had adequate HD. There was a notable variation between the tested groups in terms of HD sufficiency according to URR and KT/V (p=0.041, p<0.001 respectively). Conclusion: High-flux hemodialysis demonstrates more successful efficacy in improving biochemical parameters, including URR and KT/V, compared to low-flux hemodialysis in pediatric patients. | ||||
| Keywords | ||||
| High flux; low flux; hemodialysis; URR; KT/V | ||||
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