A Study of the Role of Some Antioxidants in Diabetes Induced in Rats | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 17, Volume 30, Issue 1, December 2010, Page 275-286 PDF (221.16 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2010.36178 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Nagy Tawfek* 1; Mahmoud Elrehany2; Adel Basyouny1; Hanaa Hassan1 | ||||
| 1Department of Zoology, Faculty of Science , El-Minia University, El-Minia, Egypt | ||||
| 2Departement of Biochemistry, Faculty of Medicine, El-Minia University, El-Minia, Egypt | ||||
| Abstract | ||||
| Oxidative stress is produced under diabetic conditions and possibly causes various forms of tissue damage and destruction of pancreatic β-cells in insulin-dependent diabetes mellitus (IDDM) patients. The present study was carried out to examine the involvement of oxidative stress in the progression of pancreatic β-cell dysfunction in type 1 diabetes and to evaluate the potential usefulness of antioxidants in the treatment of type 1diabetes. The present study was achieved using ٢٤ male Sprague Dawley albino rats. Rats were divided into three groups: normal control rats, diabetic control rats, and diabetic rats received mixture of antioxidants. A mixture of antioxidants (N-acetyl-cysteine (NAC), alpha-lipoic acid (LA), vitamin E and vitamin C) was orally administered daily to cyclophosphamide-induced diabetic rats for a period of two months. The results revealed that these antioxidants exerted amelioration in fasting plasma glucose level, significant inhibition of lipid peroxides level and observed elevation in glutathione (GSH) level and glutathione peroxidase (GPX) activity of diabetic rats. On the basis of the present results it could be concluded that (N-acetyl-cysteine (NAC), alpha-lipoic (LA), vitamin E and vitamin C) restored the activities of the studied parameters and the activities of some enzymes in different ways, depending on special mechanism in each one. Supplementation of antioxidants at once after diagnosis of diabetes may delay the complications of diabetes. This finding suggests a potential usefulness of antioxidants for treating diabetes and provides further support for the implication of oxidative stress in β-cell dysfunction in diabetes. | ||||
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