Effect of Zingerone and/or Vitamin C on the Immune System of Albino Rats, Hematological, Biochemical, Gene Expression Biomarkers and Histological Study
El Adawy, M., Abd El-Latif, A., Farrag, F., Shukry, M., Braiji, S., Hanafy, A. (2025). Effect of Zingerone and/or Vitamin C on the Immune System of Albino Rats, Hematological, Biochemical, Gene Expression Biomarkers and Histological Study. EKB Journal Management System, 56(7), 1393-1404. doi: 10.21608/ejvs.2024.278575.1949
Mohamed A A. El Adawy El Adawy; Amera Abd El-Latif; Foad Farrag; Mustafa Shukry; Shafiqah H Braiji H Braiji; Abeer Hanafy. "Effect of Zingerone and/or Vitamin C on the Immune System of Albino Rats, Hematological, Biochemical, Gene Expression Biomarkers and Histological Study". EKB Journal Management System, 56, 7, 2025, 1393-1404. doi: 10.21608/ejvs.2024.278575.1949
El Adawy, M., Abd El-Latif, A., Farrag, F., Shukry, M., Braiji, S., Hanafy, A. (2025). 'Effect of Zingerone and/or Vitamin C on the Immune System of Albino Rats, Hematological, Biochemical, Gene Expression Biomarkers and Histological Study', EKB Journal Management System, 56(7), pp. 1393-1404. doi: 10.21608/ejvs.2024.278575.1949
El Adawy, M., Abd El-Latif, A., Farrag, F., Shukry, M., Braiji, S., Hanafy, A. Effect of Zingerone and/or Vitamin C on the Immune System of Albino Rats, Hematological, Biochemical, Gene Expression Biomarkers and Histological Study. EKB Journal Management System, 2025; 56(7): 1393-1404. doi: 10.21608/ejvs.2024.278575.1949

Effect of Zingerone and/or Vitamin C on the Immune System of Albino Rats, Hematological, Biochemical, Gene Expression Biomarkers and Histological Study

Egyptian Journal of Veterinary Sciences
Volume 56, Issue 7, July 2025, Page 1393-1404  XML PDF (2.99 MB)
Document Type: Original Article
DOI: 10.21608/ejvs.2024.278575.1949
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Authors
Mohamed A A. El Adawy El Adawy1; Amera Abd El-Latif1; Foad Farrag2; Mustafa Shukry email orcid 3; Shafiqah H Braiji H Braiji4; Abeer Hanafy1
1Department of Pharmacology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt
2Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt
3Department of Physiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt
4East Jeddah General Hospita
Abstract
The immune system, a complex network of cells and chemicals, protects the body from foreign antigens. Zingerone offers significant benefits like antioxidant, anti-inflammatory, anticancer, and antimicrobial effects. Vitamin C, a potent antioxidant, shields crucial biomolecules like proteins, lipids, and nucleic acids. against oxidative damage. Forty rats were classified into control, Zingerone, vitamin C and Zingerone + vitamin C treated groups. Hematological, biochemical, gene expression, histological and Immunohistochemical investigation were used in the evaluation of both substances on the immune system. Zingerone and Vitamin C have demonstrated potential synergistic effects on blood parameters and immune function. Their antioxidant action may enhance erythropoiesis and protect against oxidative stress, while their influence on leukocyte populations could improve immune defense and regulate inflammation as well as modulate cytokine levels and surge CD4 and CD8 positive T-lymphocytes.  in conclusion These findings point to the complex interplay of dietary components in immune health and warrant further investigation for therapeutic potential.
Keywords
Zingerone; Vitamin C; Immunostimulant; Gene expression; Immunohistochemistry
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