The Role of Brain Derived Neurotrophic Factor Val66Met Polymorphism in Multiple Sclerosis Disability and Cognitive Impairment | ||||
| Zagazig University Medical Journal | ||||
| Volume 30, Issue 5, August 2024, Page 1849-1857 PDF (852.57 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2024.294297.3422 | ||||
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| Authors | ||||
Salma Mohamed Ragab1; Takwa Hosieny mohamed Elkhatib2; Eman S Elgharabawy3; Shahenda G Badran4; Shaimaa A Elaidy  5
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| 1Department of Neurology, Faculty of medicine, Kafr Elsheikh University. | ||||
| 2Department of Neurology, Faculty of medicine, Zagazig University, | ||||
| 3Department of Medical microbiology and Immunology, Faculty of medicine, Zagazig University | ||||
| 4Department of Medical microbiology and Immunology, Faculty of Medicine, Zagazig University | ||||
| 5Department of Neurology, Faculty of medicine, Zagazig University | ||||
| Abstract | ||||
| Introduction: Brain derived neurotrophic factor (BDNF) played a role in neuroplasticity and was involved in several autoimmune diseases including multiple sclerosis (MS). Val66Met polymorphism affects BDNF secretion and needs more research to determine its impact. Our work aimed at evaluating the role of this polymorphism on motor disability and cognition in MS patients. Methods: This is a case control study involving 100 subjects (50 MS patients, 50 controls). A genetic testing for BDNF Val66Met and a thorough neuropsychological evaluation using the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) in the approved Arabic version were performed for all subjects. Progressive clinical disability measurement by the Expanded Disability Status Scale (EDSS) along with the Multiple Sclerosis Severity Scale (MSSS) were done for MS patients. Results: MS patients with the Met allele variant had longer course duration (P=0.009). Val/Val genotype patients had significantly more frequent relapses (P=0.017). Met carrier patients showed lower scores on all subtests of BICAMS but only reached a statistically significant difference in the Symbol digit modality test (SDMT) (P=0.04). In the logistic regression analysis for factors predicting disability, BDNF Val66Met polymorphism was not associated with disease disability. More frequent relapses, presence of high lesion load and cervical lesions on MRI brain could predict increasing disability on multivariate analysis. Conclusion: MS patients having met allele of the BDNF gene had significant cognitive dysfunction on the SDMT. However, our results could not suggest a significant effect of this polymorphism on other subtests of BICAMS neither on the clinical disability. | ||||
| Keywords | ||||
| Multiple Sclerosis; cognition; disability; polymorphism | ||||
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