Carbapenem-resistant Klebsiella pneumoniae in COVID-19 patients admitted to intensive care units of Zagazig University Hospitals | ||||
| Microbes and Infectious Diseases | ||||
| Articles in Press, Accepted Manuscript, Available Online from 27 June 2024 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mid.2024.277993.1853 | ||||
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| Authors | ||||
Tahia Mohamed Ahmed   1; Samir A. Afifi2; Ahmad M. Hassaneen1; Mona Radwan3; Rehab Mohamed Ateya1
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| 1Department of Clinical Pathology , Faculty of Medicine, Zagazig University, Egypt | ||||
| 2Internal Medicine, Faculty of Medicine, Zagazig University, Egypt | ||||
| 3Department of community and occupational medicine, Faculty of Medicine, Zagazig University, Egypt | ||||
| Abstract | ||||
| Background: continues monitoring is crucial to detect infection by Carbapenemase-producing Klebsiella pneumoniae (CPKP) in intensive care COVID-19 patients. Aim: to evaluate the CRKP colonization and co- infection and evaluate the antibiotic resistance pattern. Patients and Methods: A cross -sectional study was done on COVID-19 patients with CPKP infection in Zagazig University Hospitals where rectal swab samples were detected using XpertCarba-R Assay(Cepheid, Sunnyvale), while isolates from sputum, urine, and blood culture were identified phenotypically by VITEK® 2 (bioMérieux SA) and modified Hodge test while genotypically by XpertCarba-R Assay(Cepheid, Sunnyvale) Results: CPKP was found in 60 patients out of 140 patients (42.8%), with 34 CPKP identified from rectal swabs, 12 patients infected from diverse locations (blood, respiratory secretions, and urine), and 14 COVID-19 patients developing CPKP co-infection with colonization. A widespread resistance to all antibiotic classes was found on the antibiograms of CPKP isolates and the blaNDM was the most common genotype detected by preliminary PCR testing Conclusion: Regarding CPKP infection a continues focus should be taken when dealing with it, particularly among COVID-19 patients. Regarding the incidence of multi-drug resistance due to nosocomial infection, can be decreased by the rigorous monitoring of colonized patients and expedite the infection control practices. | ||||
| Keywords | ||||
| COVID-19; carbapenemase; colonization | ||||
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