The promoting role of zinc oxide nano particles (Zo-NPs) enhancing the immunogenic activity of Escherichia coli lipopolysaccharides (ELPS) in vivo | ||||
| SVU-International Journal of Veterinary Sciences | ||||
| Volume 7, Issue 2 - Serial Number 20, June 2024, Page 36-42 PDF (187.99 K) | ||||
| Document Type: Research article | ||||
| DOI: 10.21608/svu.2024.285558.1317 | ||||
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| Authors | ||||
Muthanna Sultan   1; Hanen Omar Bahjat2; Sanaa Saoud Ahmed2; Bashar Sadeq Noomi2; Nihad Jafar Abdulhussain3; Hassan H. K. Al-Bayati4
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| 1Department of Microbiology, college of veterinary mediicine , Tikrit university | ||||
| 2Department of Microbiology, College of Veterinary Medicine, Tikrit University, Tikrit, Iraq, | ||||
| 3Department of Microbiology, College of Veterinary Medicine, Tikrit University, Tikrit, Iraq | ||||
| 4Department of Pathology, College of Veterinary Medicine, Tikrit University, Tikrit, Iraq | ||||
| Abstract | ||||
| Escherichia coli (E. coli) is considered one of the microorganisms that characterized as a double edge sord by their pathogenic role as well as commensal role. Lipopolysaccharides (LPS) is considered one of the endotoxins which are secreted by gram negative bacteria including E. coli Nanoparticles (NPs) are natural metals that have the ability to access through such a different micro spaces area in the body suggesting the drug delivery function of these NPs. In this current study, after uploading the LPS on the ZnO, The results of the current study suggesting the delivery role of zinc oxide giving the rise for LPS to access through more larger area surfaces in the body which leading to significant immune response of different parameters in the body including body temperature , pyrogenic activity , Antibody titration as well as the level of the proinflammatory cytokines (TNF α) compared to LPS alone. Taken together, our data indicated a significant role for the Nanoparticles particularly zinc oxide promoting the antigenic and pathogenic role of LPS compared to LPS alone, this may suggest the future role that these nanoparticles may be playing through delivering other natural compounds or drug in a consistent doses which may increasing the role of NPs in the field of drug delivery and drug safety which leading to improve the outcome of the treatment. | ||||
| Keywords | ||||
| ELPS; Immune response; Nanoparticles; Zinc Oxide | ||||
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