Possible Protective Effect of Co-administration of Hydrogen Sulfide and Exosomes versus Hydrogen Sulfide Preconditioned Exosomes on Hepatic Ischemia Reperfusion Injury in Adult Male Rat Model: Biochemical, Histological and Immunohistochemical Study
Yousry, M., Abdelmaksoud El-Deeb, D., Abd El-Sattar, E., Abdou Boughdady, W. (2024). Possible Protective Effect of Co-administration of Hydrogen Sulfide and Exosomes versus Hydrogen Sulfide Preconditioned Exosomes on Hepatic Ischemia Reperfusion Injury in Adult Male Rat Model: Biochemical, Histological and Immunohistochemical Study. EKB Journal Management System, 2(2), 7-51. doi: 10.21608/ejctr.2024.277853.1014
Marwa Mohamed Yousry; Dalia Fathy Abdelmaksoud El-Deeb; Esraa Samy Abd El-Sattar; Wafaa Abd El-Azeem Abdou Boughdady. "Possible Protective Effect of Co-administration of Hydrogen Sulfide and Exosomes versus Hydrogen Sulfide Preconditioned Exosomes on Hepatic Ischemia Reperfusion Injury in Adult Male Rat Model: Biochemical, Histological and Immunohistochemical Study". EKB Journal Management System, 2, 2, 2024, 7-51. doi: 10.21608/ejctr.2024.277853.1014
Yousry, M., Abdelmaksoud El-Deeb, D., Abd El-Sattar, E., Abdou Boughdady, W. (2024). 'Possible Protective Effect of Co-administration of Hydrogen Sulfide and Exosomes versus Hydrogen Sulfide Preconditioned Exosomes on Hepatic Ischemia Reperfusion Injury in Adult Male Rat Model: Biochemical, Histological and Immunohistochemical Study', EKB Journal Management System, 2(2), pp. 7-51. doi: 10.21608/ejctr.2024.277853.1014
Yousry, M., Abdelmaksoud El-Deeb, D., Abd El-Sattar, E., Abdou Boughdady, W. Possible Protective Effect of Co-administration of Hydrogen Sulfide and Exosomes versus Hydrogen Sulfide Preconditioned Exosomes on Hepatic Ischemia Reperfusion Injury in Adult Male Rat Model: Biochemical, Histological and Immunohistochemical Study. EKB Journal Management System, 2024; 2(2): 7-51. doi: 10.21608/ejctr.2024.277853.1014

Possible Protective Effect of Co-administration of Hydrogen Sulfide and Exosomes versus Hydrogen Sulfide Preconditioned Exosomes on Hepatic Ischemia Reperfusion Injury in Adult Male Rat Model: Biochemical, Histological and Immunohistochemical Study

Egyptian Journal of Cell and Tissue Research
Volume 2, Issue 2, June 2024, Page 7-51  XML PDF (2 MB)
Document Type: Original articles
DOI: 10.21608/ejctr.2024.277853.1014
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Authors
Marwa Mohamed Yousry email orcid ; Dalia Fathy Abdelmaksoud El-Deeborcid ; Esraa Samy Abd El-Sattarorcid ; Wafaa Abd El-Azeem Abdou Boughdadyorcid
Histology Department, Faculty of Medicine, Cairo University, Cairo, Egypt
Abstract
Background: Liver ischemia/reperfusion (I/R) commonly happens within liver surgical procedures as well as transplantation. It causes postoperative liver dysfunction, and poor patient outcome. Emerging strategies assume that efficacy of mesenchymal stem cells-exosomes (MSCs-EXOs) is dependent on status of MSCs extracellular environment. Hydrogen sulfide (H2S) regulates several cellular signaling pathways and exerts a protective effect in various disorders. Aim of the work: Comparing the protective influence of co-administration of H2S and exosomes versus H2S-preconditioned exosomes on liver I/R injury adult male rat model. Materials and Methods: Fifty adult male rats were categorized to donor, control, liver I/R, recovery, H2S + EXOs, and H2S-preconditioned EXOs groups. At the end of experiment, biochemical analysis [for liver enzymes, nuclear factor kappa-B (NF-κB) and superoxide dismutase (SOD)], histological and immunohistochemical studies [for high-mobility group box 1 (HMGB1), nuclear factor-erythroid 2-related factor 2 (Nrf2), as well as heme oxygenase-1 (HO-1)], and statistical analysis were done. Results: Ischemia/reperfusion group recorded significant rise in hepatic enzymes, NF-κB level, HMGB1 immunoreactivity, and decrease in SOD level, Nrf2 and HO-1 immunoreactivity. In addition to the presence of foci of disorganized hepatocytes, necrotic cells, apoptosis, and periportal inflammatory infiltration. Recovery showed insignificant improvement in formerly mentioned results. While the use of H2S + EXOs, or H2S-precoordinated EXOs clearly improved inflammation, antioxidant parameters, and hepatocellular injury. Conclusion: H2S + EXOs in addition to H2S-precoordinated EXOs possessed hepatoprotective impacts against I/R injury in the liver. Whereas H2S preconditioning of MSCs could augment the protective impact of MSC-EXOs.
Keywords
Hepatic I/R injury; EXOs+ H2S; H2S Preconditioned EXOs; HMGB1; Nrf2/HO1
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