Development of a Novel Removable Acrylic Orthodontic Appliance Material with Protein - Repellent and Antifungal Properties | ||||
Egyptian Dental Journal | ||||
Volume 70, Issue 3 - Serial Number 1, July 2024, Page 2201-2210 PDF (1.57 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/edj.2024.284316.3018 | ||||
View on SCiNiTO | ||||
Authors | ||||
Marwa Sameh Shamaa 1; Sayed Mohamed Ghorab 2; Nehal Fouad Albelasy 3 | ||||
1Associate Professor, Orthodontic Department, Faculty of Dentistry, Mansoura University | ||||
2Associate Professor, Dental Biomaterials, Faculty of Dentistry, Mansoura University | ||||
3Lecturer in Orthodontic Department, Faculty of Dentistry, Mansoura University | ||||
Abstract | ||||
Objective: To develop an innovative self-cure orthodontic acrylic resin containing 2-methacryloyloxyethyl phosphorylcholine (MPC) and explore the impact on protein-repellent capacity, antifungal activity, surface roughness and flexural strength. Materials and Methods: MPC was added to polymethyl Methacrylate PMMA resin in three different concentrations forming four groups (0 [control], 1.5, 3, and 4.5%). The protein adsorption was assessed utilizing a micro bicinchoninic acid method. Candida albicans biofilm activity was estimated via colony forming unit counts. Surface roughness was evaluated utilizing a Mitutoyo surface roughness tester. Flexural strength was tested in three-point flexure utilizing a Universal Testing Machine. Data were statistically analyzed using ANOVA and Tukey HSD tests (α = 0.05). Results: Incorporating MPC into the self-cure orthodontic acrylic resin significantly reduced both protein adsorption and C. albicans CFU compared to control group (p < 0.001). Adding 4.5 wt% MPC to the self-cure orthodontic PMMA resin raised the roughness values significantly (p = 0.012), while adding 1.5% and 3 % MPC resulted in no difference in roughness values to that of the control group (p > 0.05). The incorporation of 3 wt% MPC into PMMA resin significantly increased the flexural strength (P < 0.05). However, PMMA resin incorporating 4.5 wt% MPC revealed significant reduction in flexural strength compared with the control group (p = 0.009). Conclusion: A novel removable acrylic orthodontic appliance material incorporating 3 wt% MPC could achieve a promising protein repellent and antifungal activity without adversely affecting the surface roughness and flexural strength of PMMA resins. | ||||
Keywords | ||||
protein repellent; Candida albicans; flexural strength | ||||
Statistics Article View: 82 PDF Download: 59 |
||||