Effect of Selective Serotonin Reuptake Inhibitor Sertraline on Hormonal Regulation of Blood Glu | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 3, Volume 29, Issue 1, June 2009, Page 25-38 PDF (310.94 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2009.36323 | ||||
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| Authors | ||||
| Romysa El-Sherbeny* 1; Mohamed Abd-Elrhman2 | ||||
| 1Physiology Department, Faculty of Medicine, Tanta University | ||||
| 2Pharmacology Department, Faculty of Medicine, Tanta University | ||||
| Abstract | ||||
| The present work was done to investigate the effect of selective serotonin reuptake inhibitor sertraline on the hormonal regulation of blood glucose in normal and diabetic male albino rats. This work was carried out on 36 male albino rats. The rats were weighed and divided into two groups, A-Normal group: subdivided into three subgroups: Group (1): is the control group, group (2): treated by oral administration of sertraline in a dose of 30mg/kg/day through intragastric tube for one week, group(3): treated by oral sertraline in a dose of 30mg/kg/day through intragastric tube for three weeks. B-Diabetic group: diabetes was induced by single injection of 50mg/kg streptozotocin intraperitonealy to all rats, then rats subdivided into 3 subgroups. Group(1): is the control diabetic group, group (2): diabetic rats treated by oral administration of sertraline 30mg/kg/day through intragastric tube for one week, group(3): diabetic rats treated by oral administration of sertraline 30mg/kg/day through intragastric tube for three weeks. At the end of the experiment, rat were fasted for night, weighed, scarified, and blood samples were collected for determination of glucose, catecholamines, glucagon, ACTH, corticosterone and insulin levels. The results showed significant reduction of blood glucose in normal and diabetic groups after one and three weeks of treatment by sertraline. Epinephrine was significantly increased after one and three weeks of treatment in normal and diabetic groups. Norepinephrine and glucagon were significantly increased after three weeks treatment by sertraline in normal and diabetic groups. Non significant change of insulin, ACTH, corticosterone and body weight in normal and diabetic groups. It is concluded that sertraline treatment induced hypoglycemia and stimulated adrenomedullary response. It is recommended to use sertraline in diabetic patients, and to reduce the dose of antidiabetic drugs during sertraline treatment. | ||||
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