Study on the Effect of Apelin or Angiotensin-1 Receptor Blocker on Atherosclerotic Model | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 9, Volume 29, Issue 1, June 2009, Page 99-112 PDF (240.61 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2009.36331 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Maessa El-Nahas* 1; Fleur Ibrahim2; Waffa Ibrahim3 | ||||
| 1Department of Physiology, Faculty of Medicine Tanta University | ||||
| 2Department of Pharmacology, Faculty of Medicine Tanta University | ||||
| 3Department of Biochemistry, Faculty of Medicine Tanta University | ||||
| Abstract | ||||
| The aim of this study was to investigate the effect of apelin (one of adipokine) or losartan (angiotensin-1 receptor blocker) on atherosclerotic and inflammatory markers in hypercholesterelemic rats treated with angiotensin II injection. Forty male albino rats divided into two groups Control n=8 and high cholesterol diet group n = 32 which were further subdivided into 4 subgroups. Saline, AngII, AngII + losartan and AngII + apelin for 4 weeks. At the end of experiments their plasma were used and analyzed for lipid profiles, TNF-alpha, NO, CRP and SVCAM-1 where they showed significant increase in lipid profiles in saline and Ang II group and significant decrease after losartan or apelin treatment. TNF-alpha., CRP and SVCAM-1 were significantly increased after saline and Ang II, while decreased significantly after losartan or apelin. The level of NO was significantly decreased in saline and Ang II group and significantly increased after losartan or apelin. The present study indicates that apelin exerts an antiatherogenic effect and counteracts the effect of Ang II like losartan via inhibiting the atherogenic and inflammatory markers in hypercholesterelemic rats. | ||||
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