Sub clinical Vascular Inflammatory Markers, and Carotid Artery Intimal-Media Thickening in Obese Children and Adolescents | ||||
Bulletin of Egyptian Society for Physiological Sciences | ||||
Article 11, Volume 29, Issue 1, June 2009, Page 125-136 PDF (205.39 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/besps.2009.36333 | ||||
View on SCiNiTO | ||||
Authors | ||||
Saeed Hammad* 1; Mahmoud El-Gharieb2; Samy Khodeir3; Maher Abdel Hafez4 | ||||
1Department of Pediatrics, Faculty of Medicine, Omer El-Mukhtar University, Lybia | ||||
2Department of Physiology,Faculty of Medicine, Tanta University. | ||||
3Department of Internal medicine, Faculty of Medicine, Tanta University. | ||||
4Department of Pediatrics, Faculty of Medicine, Tanta University. | ||||
Abstract | ||||
Objectives: Childhood obesity contributes to the development of adult obesity and subsequent atherosclerosis, and cardiovascular disease. Associations between early morphologic and functional vascular changes as Endothelial Dysfunction, and Sub clinical vascular inflammatory soluble markers are in need for intensive assessment especially in obese childhood. The present study aimed to investigate the relationship of morphological vascular status (Carotid Artery intima-media thickness [IMT]) and functional vascular changes as plasma endothelial markers (von Willebrand factor [vWf], soluble intercellular adhesion molecule-1(sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1)), sP-selectin (sE-selectin), and high sensitive C Reactive Protein (hs-CRP) concentrations in obese children, compared with controls. Patients and methods: 35 obese children included 15 males and 20 females, and twenty five healthy lean children of matched age and sex were included in this study as a control. All underwent assessment of morphological vascular status by measuring Carotid Artery intima-media thickness [IMT]) and analysis of plasma endothelial markers (vWf, sICAM-1, sVCAM-1, sP-selectin, hs-CRP concentrations and Eselectin). Results: Our results showed that in comparison with controls, obese children demonstrated significantly increased IMT, We demonstrated that, concentrations of soluble E-selectin, sICAM-1, sVCAM-1, sP-selectin and hs-CRP concentrations were significantly elevated in obese children, whereas vWf showed no significant differences between obese children and controls. Conclusions: The present study documented that subclinical inflammation associated with obesity increase the risk of early atherosclerosis in these children. Sonographic assessment of vascular status and the estimation of soluble endothelial plasma markers, may form a rationale to identify high-risk children susceptible to early atherosclerotic disease and to monitor vascular changes during follow-up studies and therapeutic measures. | ||||
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