Association of Serum C-reactive Protein Levels with Gamma Glutamyl Transferase and Cardiometabolic Risk Factors in Middle Aged People | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 14, Volume 29, Issue 1, June 2009, Page 171-182 PDF (204.78 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2009.36336 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| Kholoud Ramadan* | ||||
| Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo Egypt | ||||
| Abstract | ||||
| C-reactive protein (CRP) is an inflammatory marker shown to predict future cardiovascular morbidity and mortality. The aim of the present study was to investigate the association of serum CRP level as a marker of chronic inflammation with gamma glutamyl transferase (GGT) as early marker of oxidative stress and their association with cardiometabolic risk factors among a diverse community sample of mid-life people, also to examine whether these relationships might vary by age, sex and body mass index. The investigation was based on data derived from 100 apparently healthy volunteers (male 40, female 60) aged 20-50 years, had a BMI between 24.2 and 37.7 kg/m2. Fasting serum CRP, GGT, uric acid and cardiovascular risk factors were measured and assessed in relation to CRP. Significant gender differences exist in the population distribution of CRP and GGT. In addition, higher BMI was significantly associated with higher CRP and uric acid. There was linear trend for increased prevalence of cardiovascular risk factors across CRP categories representing medium (1-<3mg/L) and high (3-10 mg/L). After adjustment for sex, age and body mass index, serum concentration of CRP was positively associated with serum concentration of GGT and Uric acid (P<0.05). Body mass index and systosolic blood pressure had the strongest association with CRP. The prevalence of metabolic syndrome (MS) progressively increased with elevated CRP levels. In conclusion, these data suggest that CRP is associated with two markers of oxidative stress, GGT and UA and elevation of both CRP and GGT may be worsening the atherogenic state. Furthermore, elevated CRP levels were associated with adverse lipid profiles and metabolic syndrome. | ||||
| Keywords | ||||
| Metabolic syndrome; cardiovascular diseases; C-reactive protein; BMI | ||||
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