Role of Interleukin‌7 Gene Polymorphism in Childhood Bronchial Asthma, and its Relation to Asthma Severity

Abdel Fattah, Amru Magdy; Hasan, Beshir Abdallah; Nagiub, Mohamed Sanad; Rabie, Rehab A.

doi:10.21608/zumj.2024.295112.3429

	Role of Interleukin‌7 Gene Polymorphism in Childhood Bronchial Asthma, and its Relation to Asthma Severity
Zagazig University Medical Journal
Volume 30, Issue 6, September 2024, Page 2599-2606 PDF (765.66 K)
Document Type: Original Article
DOI: 10.21608/zumj.2024.295112.3429
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Authors
Amru Magdy Abdel Fattah ¹; Beshir Abdallah Hasan²; Mohamed Sanad Nagiub²; Rehab A. Rabie³
¹Department of Pediatrics, Faculty of Medicine, Zagazig University, Amribnal-As St, Al-Salam Sednawy, Zagazig City, AlSharqia Governorate, Egypt
²Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt
³Department of Medical Microbiology & Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Abstract
Background: Variable and recurrent symptoms, reversible airflow restriction, and bronchospasm characterize asthma, a chronic long-term respiratory disease. One of the key cytokine genes in the formation of the innate and adaptive inflammatory response in the genesis of asthma is interleukin 7. There have only been a few investigations on the connection between children's asthma and interleukin-7 gene polymorphism. In order to evaluate the significance of interleukin 7 gene polymorphism in childhood bronchial asthma and its relationship to asthma severity in Egyptian children, we set out to explore SNP rs766736182. Methods: In this case-control research, 27 healthy control children and 108 patients with asthma were matched based on age. Whole blood samples were used to isolate genomic DNA. The polymorphism of the restriction fragment length polymerase chain reaction was used to identify the IL-7 polymorphism rs766736182. Results: Polymorphism of IL-7 (A missense) the risk of childhood asthma was linked to SNP rs766736182 (odds ratio (OR) = 4.69, 95% confidence interval (CI) = 1.6250-13.5791, P-value <0.001). Conclusions: This study demonstrated that the interleukin-7 SNP rs766736182 is a risk factor for childhood asthma. We found that children with asthma had higher serum levels of hs-CRP, suggesting that this marker may be useful for asthma follow up.
Keywords
Interleukin-7 polymorphism; children asthma; Cytokines; JAK inhibitors


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