The Full Motor Neurons Graft As a Preliminary Study in Rats | ||||
The Egyptian Journal of Plastic and Reconstructive Surgery | ||||
Article 8, Volume 48, Issue 3, July 2024, Page 217-222 PDF (595.66 K) | ||||
Document Type: Research article | ||||
DOI: 10.21608/ejprs.2024.365338 | ||||
View on SCiNiTO | ||||
Authors | ||||
Amr Khater* 1; Akihiko Takushima 2 | ||||
1The Department of Plastic Surgery, Faculty of Medicine, Mansoura University, Egypt | ||||
2Kyorin University School of Medicine, Tokyo | ||||
Abstract | ||||
Background: Conventional nerve grafting was used for treatment of nerve defects. However, the slow rate of nerve regeneration, donor site limitations and morbidities were considered the major disadvantages of this technique. Objective: In this article, a novel motor neuron nerve allografts were used to accelerate nerve regeneration and were compared to nerve allograft in a rat model. Methods: We harvested full motor neuron grafts and conventional nerve grafts and used them to reconstruct a ten mm defect in the motor nerve to the Extensor Digitorum communis (EDC). Results: Histological examination confirmed intact connections between the motor neurons and its axons. The mean of the amplitudes of evoked potentials of neuron graft group < br />and conventional graft group were 12.2±3.6 milliampere and 8.0±6.0 milliampere. However, muscle force, muscle weight and histological examination showed insignificant differences between the two groups. Conclusion: Full neuron transfer is a new type of nerve grafts in the rat model. As a preliminary report, we investigated the viability of the transferred nerve cells and if they worked as a booster for augmentation of the signals. Electrophysiological examinations showed favorable results and histological studies showed the survival of the motor neurons outside the central nervous system. | ||||
Keywords | ||||
Neuron graft; Nerve graft – Wallerian degeneration – Nerve regeneration | ||||
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References | ||||
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