Serum Retinoic Acid as a Predictor of Cognitive Impairment after Acute Ischemic Stroke | ||||
| Zagazig University Medical Journal | ||||
| Volume 30, Issue 6, September 2024, Page 2578-2587 PDF (833.93 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2024.299390.3452 | ||||
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| Authors | ||||
Khaled Aly El-Sharkawy1; Iman Mosbah Abdelgawad  1; Takwa Hoseiny Mohamed1; Rania Yehia Helal2
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| 1Neurology Department, Faculty of Medicine, Zagazig University | ||||
| 2neurology department,faculty of medicine,zagazig university,Zagazig,Egypt | ||||
| Abstract | ||||
| Background: Post ischemic stroke cognitive impairment (PSCI) is one of the most prevalent complications of ischemic stroke affecting the brain with negative impact on daily activity, quality of life of ischemic stroke survivors, their families and society. These topics are gaining scholarly attention and may indicate to new avenues for action in the prevention and treatment of PSCI so that they have better quality of life. Previous studies about novel diagnostic biomarkers of PSCI are rare. We speculated that circulating retinoic acid (RA) level might be a prognostic biomarker relating to PSCI. Aim: Early detection of cognitive impairment among patients with first-ever acute ischemic stroke. Methods: This prospective cohort study has been carried out in Stroke and Intensive Care Units, Neurology Department, Zagazig Universty Hospitals on patients who develop first ever acute ischemic stroke within 7 days of stroke onset. Retinoic acid was measured in all cases. Results: Retinoic acid was significantly higher among patients with PSCI compared to patients without. Only lower levels retinoic acid and severe NIHSS were significantly associated factors with PSCI. Conclusion: In a cohort of patients with ischemic stroke, lower blood RA levels was associated with an increased risk of 3-month PSCI. | ||||
| Keywords | ||||
| Retinoic Acid; Post Ischemic Stroke Cognitive Impairement; Montreal Cognitive Assessment | ||||
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