Anti-Mullerian Hormone Serum Concentrationsin Women with Polycystic Ovaries and Normoovulatory Women of Reproductive Age
Al-Tahhan, M., El-Gendi, S., Diab, A. (2009). Anti-Mullerian Hormone Serum Concentrationsin Women with Polycystic Ovaries and Normoovulatory Women of Reproductive Age. EKB Journal Management System, 29(2), 119-130. doi: 10.21608/besps.2009.36688
Magdy Al-Tahhan; Selem El-Gendi; Abdallah Diab. "Anti-Mullerian Hormone Serum Concentrationsin Women with Polycystic Ovaries and Normoovulatory Women of Reproductive Age". EKB Journal Management System, 29, 2, 2009, 119-130. doi: 10.21608/besps.2009.36688
Al-Tahhan, M., El-Gendi, S., Diab, A. (2009). 'Anti-Mullerian Hormone Serum Concentrationsin Women with Polycystic Ovaries and Normoovulatory Women of Reproductive Age', EKB Journal Management System, 29(2), pp. 119-130. doi: 10.21608/besps.2009.36688
Al-Tahhan, M., El-Gendi, S., Diab, A. Anti-Mullerian Hormone Serum Concentrationsin Women with Polycystic Ovaries and Normoovulatory Women of Reproductive Age. EKB Journal Management System, 2009; 29(2): 119-130. doi: 10.21608/besps.2009.36688

Anti-Mullerian Hormone Serum Concentrationsin Women with Polycystic Ovaries and Normoovulatory Women of Reproductive Age

Bulletin of Egyptian Society for Physiological Sciences
Article 9, Volume 29, Issue 2, December 2009, Page 119-130  XML PDF (247.91 K)
Document Type: Original Article
DOI: 10.21608/besps.2009.36688
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Authors
Magdy Al-Tahhan* 1; Selem El-Gendi2; Abdallah Diab2
1Medical Biochemistry Department,Faculty of Medicine, Zagazig, University.
2Obstetric & Gynecology Department,Faculty of Medicine, Zagazig, University.
Abstract
Background: Anti-Mullerian hormone (AMH) is a member of the transforming
growth factor-βsuperfamily. It may play an important role in the ovarian
folliculogenesis.Objective:To study the relationship of AMH and some clinical,
endocrinal and ultrasound parameters in anovulatory infertile women with polycystic
ovary syndrome (PCOS) and in women with normal menstrual cycles. Methods:Sera
were collected from 30 PCOS anovulatory women and from 15 normal women during
the early follicular phase "day 3" of the menstrual cycle, stored frozen until assayed.
Results:Serum AMH concentrations were significantly (P<0.001) elevated in PCOS
women (9.55±3.39 μg/liter) compared with controls (2.33±1.8 μg/liter). In PCOS
patients, serum levels of AMH were correlated with features characteristics of PCOS
such as LH concentrations (r=0.76, P<0.001), testosterone level (r=0.67, P<0.001),
mean number of follicles (r=0.68, P<0.001)and ovarian volume (r=0.54, P<0.001).
Also, AMH levels were correlated withage (r=-0.51, P<0.001) and with cycle
duration (r=0.46, P<0.001). The correlation between AMH levels and FSH, estradiol
or BMI were found statistically non significant. Conclusion:The present study
provides evidence that serum levels of AMH is elevated in PCOS patients. This may
have a role in the disordered folliculogenesis characteristics of that disease.
Keywords
Anti-Mullerian hormone; polycystic ovary syndrome
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