Serum Nerve Growth Factor, Interleukin-13 and Tumor Necrosis Factor - Αin patients with Systemic Lupus Erythematosus | ||||
Bulletin of Egyptian Society for Physiological Sciences | ||||
Article 11, Volume 29, Issue 2, December 2009, Page 151-164 PDF (235.85 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/besps.2009.36701 | ||||
View on SCiNiTO | ||||
Authors | ||||
Magdy Al Tahhan* 1; Mervat El-Toukhy2; Ehab Salem3 | ||||
1Medical Biochemistry Department, Faculty of Medicine, Zagazig University | ||||
2Rheumatology & Rehabilitation Department, Faculty of Medicine, Zagazig University | ||||
3Internal Medicine Department, Faculty of Medicine, Zagazig University | ||||
Abstract | ||||
systemic lupus erythematosus(SLE) is an autoimmune disease characterized by B-cell hyperactivity, production of autoantibodyand abnormal immunoregulation. At present, both interleukin-13(IL-13) and nerve growth factor(NGF) have been proved to play a role in stimulating the proliferation and differentiation of human B-cells and inducing immunoglobulin(Ig) synthesis.Tumor necrosis factor-a(TNF-a) is both a proinflammatory and immunomodulatory cytokine. It was suggested to affect NGF expression. Therefore, the present study was designed to determine serum NFG, IL-13 and TNF-αin 31 patients with systemic lupus erythematosus (SLE) and to assess their relationship with the disease activity as measured by SLE Disease Activity Index (SLEDAI). The results showed that the levels of serum NGF (308±85 pg/ml), IL-13(92.69±9.87 pg/ml) and TNF-a (50.6±11.3 pg/ml) in active SLE patients were significantly higher than those in inactive SLE patients (NGF, 244±76 pg/ml;IL-13, 54.22±9.31 pg/ml;TNF-a,29.4±9.8 pg/ml)(p<0.01. The inactive patients also had significantly increased serum levels of NGF, IL-13 and TNF-a as compared with normal controls( NGF,72.29±23.6 pg/ml;IL-13, 35.20±12.70 pg/ml; TNF-a,8.7±3.0 pg/ml)(p<0.001). Spearman correlation analysis revealed that the serum levels of NGF,IL-13 and TNF-a were correlated with disease activity index of SLE(SLEDAI),ESR and serum levels of C3 and C4( NGF, r=0.442 , - 0.41, - 0.38 ; IL-13, r=0.813 , -0.504 , -0.605 ;TNF-a, r=0.69,-0.43,-0.52 respectively).The serum levels of NGF, IL-13 and TNF-a had a positive correlation ( r=0.506, p<0.01). Significant positive correlations were observed between NGF, TNF-a and SLEDAI. Also, a significant positive correlation was present between TNF-a and NGF suggesting that elevated TNF-a levels may lead to a continued increase of NGF production. In conclusion, the present results suggest that NGF, IL-13 and TNF-α may play a role in the pathogenesis of SLE and closely correlated with the disease activity, therefore they could be used as sensitive markers for evaluating the disease activity. | ||||
Keywords | ||||
NGF; IL-13 and; TNF-; Systemic lupus erythematosus | ||||
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