Cyclosporine-Induced Oxidative Stress and renal Dysfunction in Rat kidneys: A Possible Ameliorated Effect by Curcumin as an Antioxidant
Heibashy, M., El-Nahrawy, W., Zaki, N. (2009). Cyclosporine-Induced Oxidative Stress and renal Dysfunction in Rat kidneys: A Possible Ameliorated Effect by Curcumin as an Antioxidant. EKB Journal Management System, 29(2), 179-194. doi: 10.21608/besps.2009.36716
Mohamed Heibashy; Walaa El-Nahrawy; Nashwa Zaki. "Cyclosporine-Induced Oxidative Stress and renal Dysfunction in Rat kidneys: A Possible Ameliorated Effect by Curcumin as an Antioxidant". EKB Journal Management System, 29, 2, 2009, 179-194. doi: 10.21608/besps.2009.36716
Heibashy, M., El-Nahrawy, W., Zaki, N. (2009). 'Cyclosporine-Induced Oxidative Stress and renal Dysfunction in Rat kidneys: A Possible Ameliorated Effect by Curcumin as an Antioxidant', EKB Journal Management System, 29(2), pp. 179-194. doi: 10.21608/besps.2009.36716
Heibashy, M., El-Nahrawy, W., Zaki, N. Cyclosporine-Induced Oxidative Stress and renal Dysfunction in Rat kidneys: A Possible Ameliorated Effect by Curcumin as an Antioxidant. EKB Journal Management System, 2009; 29(2): 179-194. doi: 10.21608/besps.2009.36716

Cyclosporine-Induced Oxidative Stress and renal Dysfunction in Rat kidneys: A Possible Ameliorated Effect by Curcumin as an Antioxidant

Bulletin of Egyptian Society for Physiological Sciences
Article 13, Volume 29, Issue 2, December 2009, Page 179-194  XML PDF (196.64 K)
Document Type: Original Article
DOI: 10.21608/besps.2009.36716
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Authors
Mohamed Heibashy* 1; Walaa El-Nahrawy2; Nashwa Zaki3
1Biological Applications Department, Nuclear Research Center, Atomic Energy Authority
2Zoology Department, Girl's Collage, Ain Shams University
3Hepatology and Tropical Diseases Nation Institute, Cairo
Abstract
Curcumin (CMN) has been well studied due to its economic and medical importance.
Traditional Egyptian Medicine claims the use of its powder against biliary disorders,
anorexia, coryza, cough, diabetic wounds, hepatic disorder, rheumatism and sinusitis.
The current study was designed to examine the possible beneficial effect of CMN in
preventing the acute renal failure and related oxidative stress caused by chronic
administration of cyclosporine (CsA) in rats. The study included two experiments, the
first one was carried out to follow up the changes that could occur in kidney function
as a result of cyclosporine (CsA) administration. Cyclosporine administration exerted
significant (P< 0.01) elevation of serum urea, creatinine, potassium (K),
parathormone (PTH), malondialdehyde (MDA) and asymmetrical dimethylarginine
(ADMA). Meanwhile, cyclosporine treatment exerted significant (P< 0.01) decline in
the level of serum sodium (Na) and total nitric oxide (NO), the content of kidney
reduced glutathione (GSH) and the activities of glutathione peroxidase (G
px), catalase
(CAT) and superoxide dismutase (SOD) as compared with their corresponding
normal rats. In the second experiment, the nephritic rats were treated with curcumin
and remarkable corrections were occurred in all previous parameters. Thus, the
current investigation was designed to examine the possible beneficial effect of CMN
in preventing the renal failure and related oxidative stress caused by administration
of CsA in rats.
Keywords
Cyclosporine; Curcumin; Kidney function tests; Rats
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