Oral vitamin C administration Decreases Training Efficiency and Muscle Mitochondrial Biogenesis in Rats
El-Sekelly, S., Hasan, M., Abd Allah, I. (2009). Oral vitamin C administration Decreases Training Efficiency and Muscle Mitochondrial Biogenesis in Rats. EKB Journal Management System, 29(2), 207-218. doi: 10.21608/besps.2009.36720
Saad El-Sekelly; Mohamed Hasan; Ibrahem Abd Allah. "Oral vitamin C administration Decreases Training Efficiency and Muscle Mitochondrial Biogenesis in Rats". EKB Journal Management System, 29, 2, 2009, 207-218. doi: 10.21608/besps.2009.36720
El-Sekelly, S., Hasan, M., Abd Allah, I. (2009). 'Oral vitamin C administration Decreases Training Efficiency and Muscle Mitochondrial Biogenesis in Rats', EKB Journal Management System, 29(2), pp. 207-218. doi: 10.21608/besps.2009.36720
El-Sekelly, S., Hasan, M., Abd Allah, I. Oral vitamin C administration Decreases Training Efficiency and Muscle Mitochondrial Biogenesis in Rats. EKB Journal Management System, 2009; 29(2): 207-218. doi: 10.21608/besps.2009.36720

Oral vitamin C administration Decreases Training Efficiency and Muscle Mitochondrial Biogenesis in Rats

Bulletin of Egyptian Society for Physiological Sciences
Article 15, Volume 29, Issue 2, December 2009, Page 207-218  XML PDF (195.17 K)
Document Type: Original Article
DOI: 10.21608/besps.2009.36720
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Authors
Saad El-Sekelly* 1; Mohamed Hasan2; Ibrahem Abd Allah3
1Biochemistry Dept. Faculty ofMedicine, Minia University
2Theoretical and Application Group sports Dept. Faculty of Sport Education, Zagazig University
3Physiology Dept. Faculty of Medicine, Minia University
Abstract
Exercise practitioners often take vitamin C supplements because intense muscular
contractile activity can result in oxidative stress, as indicated by altered muscle and
blood glutathione concentrations and increases in protein, DNA, and lipid
peroxidation. There is, however, considerable debate regarding the beneficial health
effects of vitamin C supplementation. The present study was designed to study the
effect of vitamin C on training efficiency in rats. Thirty male Albino rats were
exercised under protocol for 6 weeks. Ten of the rats were treated with a daily dose of
500 mg/kg body weight of vitamin C (0.24 mg/cm2 body surface area). The
administration of vitamin C hampered endurance capacity. The adverse effects of
vitamin C may result from its capacity toreduce the exercise-induced expression of
key transcription factors involved in mitochondrial biogenesis. These factors are
nuclear respiratory factor 1and mitochondrial transcription factor A. Vitamin C also
prevented the exercise-induced expression ofthe antioxidant enzymes superoxide
dismutase and glutathione peroxidase. The study showed that Vitamin C
supplementation decreases training efficiency because it prevents some cellular
adaptations to exercise.
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