Study of Mean platelet volume in type 2 diabetes mellitus
Al Refaee, E., Hassanin, H., Boghdady, A., Mohamad, H. (2017). Study of Mean platelet volume in type 2 diabetes mellitus. EKB Journal Management System, 21(3), 135-142. doi: 10.21608/smj.2017.36750
El Hussieny Yousef Al Refaee; Hassan Ahmed Hassanin; Ahmed Mohamed Boghdady; Hamdy Saad Mohamad. "Study of Mean platelet volume in type 2 diabetes mellitus". EKB Journal Management System, 21, 3, 2017, 135-142. doi: 10.21608/smj.2017.36750
Al Refaee, E., Hassanin, H., Boghdady, A., Mohamad, H. (2017). 'Study of Mean platelet volume in type 2 diabetes mellitus', EKB Journal Management System, 21(3), pp. 135-142. doi: 10.21608/smj.2017.36750
Al Refaee, E., Hassanin, H., Boghdady, A., Mohamad, H. Study of Mean platelet volume in type 2 diabetes mellitus. EKB Journal Management System, 2017; 21(3): 135-142. doi: 10.21608/smj.2017.36750

Study of Mean platelet volume in type 2 diabetes mellitus

Sohag Medical Journal
Article 16, Volume 21, Issue 3, October 2017, Page 135-142  XML PDF (79.17 K)
Document Type: Original Article
DOI: 10.21608/smj.2017.36750
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Authors
El Hussieny Yousef Al Refaee1; Hassan Ahmed Hassanin2; Ahmed Mohamed Boghdady3; Hamdy Saad Mohamad1
1Department , of Internal Medicine , Faculty of Medicine, Sohag University
2Department of Internal Medicine, Faculty of Medicine, Sohag University.
3Department of Internal Medicine, Faculty of Medicine, Sohag University
Abstract
Background: Altered platelet morphology and function have been reported in patients with diabetes mellitus. They are likely to be associated with the pathological processes and increased risk of vascular disease seen in these patients. We aimed to determine the mean platelet volume (MPV) in diabetics compared to nonediabetics, to see if there is a difference in MPV between diabetics with and without macro and microvascular complications, and to determine the correlation between MPVand fasting blood glucose, glycosylated hemoglobin (HbA1c), patient age, and duration of diabetes, respectively.
Methods: We measured MPV in 100 consecutive Type 2 diabetic patients and 50 non diabetic control subjects without known coronary artery disease who had complete blood count, FBG, HbA1c, serum creatinine and ALB/Creat ratio. Statistical evaluation was performed by SPSS for Windows statistics programme using multivariate logistical regression analysis.
Results: MPV was significantly higher in diabetics compared to age- and sex-matched nonediabetic healthy controls, significantly higher with complicated DM compared to none complicated DM, and significantly higher with poor glycemic control compared to good glycemic control. 
Conclusions: Our results show significantly higher MPV in diabetic patients than in the nonediabetic controls. This suggests that platelets may play a role in the micro and macrovascular complications of diabetic patients.
Supplementary Files
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