Role of Annona muricata (L.) in oxidative stress and metabolic variations in diabetic and gamma-irradiated rats | ||||
| Egyptian Journal of Radiation Sciences and Applications | ||||
| Article 8, Volume 30, Issue 1, December 2017, Page 73-83 PDF (1.46 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejrsa.2017.1183.1012 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mina Sabry Kamal  1; Ehab Tawfik Mohamed2; El-Sayed Mohamed Mahdy3; Gamal Ahmed Singer4; Shereen Mohamed Elkiki5
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| 1National Research centre of Radiation,Nasr city , Cairo | ||||
| 2National Center for Radiation Research and Technology,Nasr City, Cairo, Egypt. | ||||
| 3Chemistry Department, Faculty of Science, Helwan University, Egypt | ||||
| 4Chemistry/Biochemistry Department, Faculty of Science, Helwan University,Cairo, Egypt. | ||||
| 5National Center for Radiation Research and Technology, Atomic Energy Authority, P.O Box 29, Nasr City, Cairo, Egypt. | ||||
| Abstract | ||||
| A. muricata L., commonly known as graviola, is a plant widely distributed throughout the world rich in phytochemicals and minerals. The objective of this study was to investigate the influence of A.muricata on oxidative stress in the liver, kidney and pancreas along with variations in glucose, insulin, lipid profile, liver and kidney functions in diabetic (DM) and γ-irradiated rats (IRR). Diabetes was induced by a single intraperitoneal injection of streptozotocin (65 mg/Kg body weight). Irradiation was performed as whole body γ-irradiation (5 Gy) administered in a single acute dose. A.muricata leaves aqueous extract (100 mg/Kg body weight) was administered via gavages during 2 weeks to diabetic rats or during 2 weeks before γ-irradiation. Diabetic rats received A. muricata during 2 weeks before irradiation. Animals were sacrificed 24 hours post irradiation and/or A. muricata trearment. A. muricata treatment has significantly attenuated hyperglycemia, hypoinsulinemia and dyslipidemia, and reduced the increase of serum alanine and aspartate amino transferase activities and serum urea and creatinine levels. The amelioration in metabolic variations was associated to significant improvement of oxidative stress in tissues notified by a higher superoxide dismutase (SOD) activity and glutathione (GSH) content and a lower malondialdehyde (MDA) content. It could be suggested that the synergistic relationship between the different elements found in the leaf of A.muricata could be beneficial in ameliorating liver and kidney function and correcting metabolic variations associated with oxidative stress in the liver, kidney and pancreas. | ||||
| Keywords | ||||
| diabetes; streptozotocin; γ-irradiation; A.muricata; Oxidative Stress; metabolic variations | ||||
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