Effect of Green Tea and Vitamin C on Rheumatoid Arthritis of Male Albino Rat Induced with Collagen II | ||||
Bulletin of Egyptian Society for Physiological Sciences | ||||
Article 3, Volume 28, Issue 1, June 2008, Page 17-32 PDF (220.1 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/besps.2008.36808 | ||||
View on SCiNiTO | ||||
Authors | ||||
Mona EL-Karn* 1; Abdel-Raheim Meki2; Hafez Madkor3 | ||||
1Department of Physiology , Faculty of Medicine, Assiut University, Assiut, Egypt | ||||
2Department of Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt | ||||
3Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt | ||||
Abstract | ||||
In the present study, the biochemical effects of vitamin C, and aqueous extract of green tea (GTE) on rheumatoid arthritis (RA) of rats were investigated. The oxidative stress indices and the antioxidant levels were evaluated. Forty albino male rats were divided into four groups (10 rats each): control group, collagen II -induced RA group (C II group), CII group treated with vitamin C (C II + Vit. C), and CII group treated with green tea extract (GTE) (C II + GTE). After 6 weeks of antioxidants treatment, the plasma levels of lipid peroxides (LPO), nitric oxide (NO), ceruloplasmin (PC), and glutathione (GSH) were detected using colorimetric methods. The plasma levels ofcopper (Cu) and zinc (Zn)were determined using atomic absorption/flame emission spectrometer. In C II treated group, the levels of LPO, NO, CP and Cu were significantly higher but the levels of; GSH and Zn were significantly lower than controls. The levels of GSH and Zn were significantly increased but the levels of NO, Cu and CPwere significantly decreased in the vitamins C treated groups in comparison with C II –treated group. In the C II + GTE group, the levels of LPO, NO, CP and Cu were significantly decreased but the levels of GSH, and Zn were significantly increased in comparison with C II –treated group. The present study suggests that proper antioxidants intake may reduce free radical generation and improve antioxidant status in RA. GTE and vitamin C may effectively normalize in different degrees the impaired oxidant/ antioxidant system and may be useful in delaying the complication of RA. | ||||
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