Effect of Melatonin on SomeOxidative Stress Parameters in Streptozotocin-Induced Diabetes in Rats | ||||
Bulletin of Egyptian Society for Physiological Sciences | ||||
Article 10, Volume 28, Issue 1, June 2008, Page 121-140 PDF (359.05 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/besps.2008.36843 | ||||
View on SCiNiTO | ||||
Authors | ||||
Manal AlBatch* 1; Fathy ElFasakhany1; Abdel Sheta2; Safwat Kasim1 | ||||
1Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Egyp | ||||
2Department of Anatomy, Faculty of Medicine, Tanta University, Egypt | ||||
Abstract | ||||
Diabetes mellitus has been shown to be a state of increased free radicals and disturbance in antioxidant defense system. The aim of the present study was to investigate the protective effect of melatonin on some oxidative stress parameters in both blood and tissues, liver and pancreas, in streptozotocin (STZ)-induced diabetes in rats. Three groups of rats were used, control group, diabetic group and a group of diabetic rats treated with melatonin. Malondialdehyde (MDA) level was used as a marker of lipid peroxidation, advanced oxidation protein product (AOPP) level as a marker for protein damage and activity of antioxidant enzymes; glutathione peroxidase (GPx) and paraoxonase (PON) were, also, assessed. Liver and pancreatic malondialdehyde and plasma AOPP levels were significantly reduced but serum PON1 and pancreatic GPx activities were significantly increased by melatonin treatment. Liver GPx activities showed no significant differences among all studied groups. Microscopic examination of liver showed improvement of the morphological and histopathological changes induced by diabetes. These data suggested that melatonin treatment has a partial therapeutic effect in diabetes by reduction of oxidative stress and by stimulation of various antioxidant enzymes. | ||||
Keywords | ||||
STZ; Melatonin; Oxidative Stress; MDA; Diabetes mellitus | ||||
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