Facile one-pot strategy for brain imaging using radiolabeled [99mTc]-tricarbonyl histamine complex in Mice. | ||||
Egyptian Journal of Chemistry | ||||
Articles in Press, Accepted Manuscript, Available Online from 21 July 2024 | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejchem.2024.283339.9602 | ||||
View on SCiNiTO | ||||
Authors | ||||
Safaa Bekheet Challan 1; Mahmoud Hamdi Sanad 2; Sayed Mohamed Abdelhaleim3; Fatma Abdo yehia4; Aiten Mohmoud Soliman4; Nermeen Mohamed El Bakry5; Hanan Mohamed Essa6; Ayman Bastawy Farag7 | ||||
1Labeled Compounds Department, Hot Laboratories Center, Egyptian Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt | ||||
2Labeled Compounds Department, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo, Egypt. | ||||
3Labeled Compound Department, Hot Laboratory Center, Egyptian Atomic Energy Authority | ||||
42Drug Radiation Research Department, National Centre for Radiation Research and Technology, Egyptian Atomic Energy, Authority, P.O. Box 11787, Cairo, Egypt. | ||||
5Radiation Biology Department, National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt | ||||
6Radiation Chemistry Department, National Centre for Radiation Research and Technology,Egyptian Atomic Energy, Authority, Cairo, Egypt. | ||||
73Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, 12578 Egypt. | ||||
Abstract | ||||
This investigation aims to label the histamine ligand, 2-(1H-imidazol-4-yl) ethanamine, using a [99mTc]-tricarbonyl core method for brain imaging. The optimization of all variables and factors influencing the radiochemical reaction is carried out to produce the labeled compound with a high radiochemical yield of 98.5%. The radiolabeled compound was stable for up to 6 hours, with a logarithm of the partition coefficient value at 1.49 ± 0.04. This value suggests the lipophilic characteristics of the [99mTc]-tricarbonyl histamine compound, indicating its potential to cross the blood-brain barrier effectively. The bioevaluation of the radiotracer [99mTc]-tricarbonyl-histamine complex exhibited a notable brain uptake of 8.5% ID/organ at 5 minutes post-injection and, eliminated through the urinary system within 2 hours post-injection. This study explores the promising developments in brain imaging facilitated by the [99mTc]-tricarbonyl histamine complex. | ||||
Keywords | ||||
Histamine ligand; Radiolabeled; [99mTc]-tricarbonyl core; bioevaluation; brain imaging | ||||
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