Alpha-1 antitrypsin and vitamin D deficiency in COVI-19: correlation with risk of disease in Iraqi patients. | ||||
| Microbes and Infectious Diseases | ||||
| Articles in Press, Accepted Manuscript, Available Online from 22 July 2024 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mid.2024.268842.1798 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Alaa Hussein Hasan  
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| Ibn Sina University of Medical and Pharmaceutical Science, Baghdad, Iraq | ||||
| Abstract | ||||
| Background: The pandemic COVID-19 was generated by severe acute respiratory syndrome [SARS] coronavirus( CoV2). A fast viral broadcasting leads to an unexpected increase of the number of cases in the world. Like the SARS -CoV2 infection case report the Italian alpha 1 antitrypsin registry conclusions demonstrated an adjacent geographic spreading of positive cases. A highest infected rates were demonstrated in peoples deficient with Alpha-1 antitrypsin(AAT). In our study we aimed to evaluate links of plasma alpha-1 antitrypsin and vitamin D with the risk COVID-19, and whether it explained the higher incidence of COVID-19. Methods: One hundred and eight person with mean age 49 years, from them 54 patients (33.3% male and 66.6 female ) had COVID-19 infection and 54 heathy person. Alpha-1 antitrypsin (AAT), vitamin D and C-reactive protein (CRP) checks were done for all of them. Results: Regarding the AAT their was a highly significant difference(p<0.05) among the groups where the average of the concentration in patients lower than that in healthy 0.99 (mg/dl) and 4.33(mg/dl) spontaneously, also there was a highly significant difference(p<0.05) between the two groups regarding to vitamin D level that in patients 9.97 ng/ml lower that in healthy persons 34.22 ng/ml. While the average of CRP 119.43(µg/ml) in infected persons and 6.33(µg/ml) in non infected persons with a highly significant difference (p<0.05). Conclusion: There was an association between COVID-19 infection with the levels of alpha-1 antitrypsin, vitamin D, CRP. | ||||
| Keywords | ||||
| COVID-19; alpha-1 antitrypsin; vitamin D; C-reactive protein | ||||
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