Evaluation of Homocysteine and Plasminogen Activator Inhibitor-1 Changes in Age Related Macular Degeneration | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 18, Volume 28, Issue 1, June 2008, Page 253-264 PDF (315.94 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2008.36961 | ||||
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| Authors | ||||
| Amany Mahmoud* 1; Kareem Risk2 | ||||
| 1The Department of Biochemistry Research Institute of Ophthalmology | ||||
| 2The Department of Ophthalmology Research Institute of Ophthalmology | ||||
| Abstract | ||||
| Age-related maculopathy (ARM) and its late stage, age-related macular degeneration (ARMD), are degenerative disorders of the central part of the macula. They are the leading cause of visual impairment and legal blindness among older persons. The cause of ARMD remains unknown, previous studies suggest an association of markers of angiogenesis, hemostasis, and endothelial dysfunction with ARMD. The role of homocysteine and PAI-1have been more controversial, so the purpose of this study was to evaluate the association between levels of plasma homocysteine and PAI-1 and age-related macular degeneration (ARMD). Forty eight age –related macular degeneration cases (23 atrophic and 25 exudative neovascular forms) and 30 controls with matched age and sex distribution were included in this study. Body mass index (BMI), lipid profile, plasma leptin, homocysteine and plasminogen activator inhibitor-1(PAI-1) levels were estimated. The present study points to an association of ARMD and dyslipidemia, and obesity. Also, there were a significant increase in the levels of plasma homocysteine and PAI-1 in exudative neovascular age-related macular degeneration (“wet” type). There was a highly positive correlation between level of leptin and PAI-1 and BMI in exudative neovascular form. In conclusion,the present study provides solid evidence that impaired fibrinolysis probably related to obesity, acting in concert with hyperhomocysteinemia may be involved in the pathogenesis of age-related macular degeneration. The strategies aimed at reducing the level of homocysteine and controlling the overproduction of plasminogen activators inhibitor-1 might offer protection against retinal damage in blinding retinal diseases especially exudative neovascular age-related macular degeneration. | ||||
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