Phytochemicals Screening, Antioxidant and Anticancer Activities of Garlic (Allium sativum) Extracts | ||||
| Journal of Agricultural Chemistry and Biotechnology | ||||
| Article 2, Volume 10, Issue 4, April 2019, Page 79-82 PDF (521.33 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jacb.2019.36985 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| H. El-khamissi; Z. Saad; H. Rozan | ||||
| Biochemistry Department, Faculty of Agriculture, Al-Azhar University, Cairo, Egypt | ||||
| Abstract | ||||
| The objective of this study is to determine the phytochemicals of garlic, antioxidants and anticancer activities against cancer cell line (MCF-7) of hot water, cold water and ethanol extracts of garlic (Allium Sativum). The results showed that garlic contains more than 80% total carbohydrates and proteins. Also, qualitative phytochemical analysis of garlic extracts indicated the presence of flavonoids, alkaloids, tannins, phenols, saponins, terpenoids, steroids and phytosterols in ethanol and hot water extracts, whereas alkaloids and saponins are absent in cold water extract. Moreover, antioxidant activity of garlic extracts by DPPH method showed a strong effect on the activity scavenging of free radicals. In addition, ethanol extract had higher reducing power, total flavonoids and total phenolics contents in comparison with hot water and cold water extracts. Finally, garlic extracts also showed very high cytotoxic activity against human breast cancer cell line type (MCF-7) especially ethanol extract, which makes us recommend that garlic is useful as a rich antioxidant and has great strength against cancer cells. | ||||
| Keywords | ||||
| Allium sativum; phytochemicals; Total flavonoids; Total Phenolics; DPPH; MCF-7 | ||||
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