Doxorubicin-eluting beads versus combined conventional transarterial chemoembolization and percutaneous alcohol injection in the treatment of large hepatocellular carcinoma | ||||
| Journal of Current Medical Research and Practice | ||||
| Volume 2, Issue 2, May 2017, Page 105-110 PDF (218.04 K) | ||||
| DOI: 10.4103/JCMRP.JCMRP_2_17 | ||||
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| Authors | ||||
| Ahlam M. A. Farghaly; EhabFawzy A. Moustafa; Hany M. A. Seif; Moustafa H. M. Othman; Reda H. M. Tabashy; Mohammed O. A. Abdelglil; Essam Eldeen M. O. Mahran | ||||
| Abstract | ||||
| Introduction Hepatocellular carcinoma (HCC) is a primary tumor of the liver, which usually develops in the setting of chronic liver disease, particularly in patients with chronic hepatitis B and hepatitis C. Current guidelines recommend transarterial chemoembolization (TACE) as the standard treatment of Barcelona Clinic Liver Cancer-B patients. The aim of this work is to compare the efficacy, safety, feasibility, and cost-effectiveness of drug-eluting bead (DEB)-TACE versus combined conventional transarterial chemoembolization (c-TACE)+percutaneous ethanol injection (PEI) for improving the outcome of large HCC. Patients and methods In all, 75 patients with large HCC were included in this study: 30 patients were treated by combined c-TACE + PEI and 45 patients were treated by DEB-TACE. Results By comparison of the results of the combined c-TACE + PEI group with the DEB-TACE group, there was no significant difference in tumor response, with better results in the combined c-TACE + PEI group and significant decrease in the median value of the serum level of α-fetoprotein after treatment among patients treated with combined c-TACE + PEI ( = 0.004), and a statistically significant difference in the median value after treatment between the two groups ( = 0.036). Conclusion Results of combined c-TACE + PEI and DEB-TACE are comparable, but the cost of a DEB-TACE session is three times that of c-TACE + PEI, and thus cost-effectiveness analyses recommend the use of combined c-TACE + PEI (less cost) in the treatment of large HCC; in addition, there was a significant reduction in the level of α-fetoprotein after combined c-TACE+PEI treatment. | ||||
| Keywords | ||||
| doxorubicin beads; Hepatocellular carcinoma; percutaneous alcohol; transaretrial chemoembolization | ||||
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