Beneficial Effects of Ginger as Hypoglyemic, Hypolipidemic, Anti-obesity, Anti-oxidant, and Anti-inflammatory Agent in Adult Female albino Rats | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 22, Volume 28, Issue 1, June 2008, Page 325-336 PDF (139.43 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2008.36994 | ||||
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| Authors | ||||
| Mona El-Karn* 1; Sahar El-Deek2; Amany Osama2 | ||||
| 1Medical Physiology Departement Faculty of Medicine, Assiut University | ||||
| 2Medical Biochemistry Departement Faculty of Medicine, Assiut University | ||||
| Abstract | ||||
| Ginger is one of the more commonly used herbal supplements. Although often consumed for culinary purposes, it is taken by many patients to treat a variety of conditions. Currently, there is a renewed interest in ginger, and several scientific investigations aimed at isolation and identification of active constituents, and verification of the basis of the use of ginger in some of several diseases and conditions. The present work aimed to evaluate the beneficial effects of ginger as hypoglycemic, hypolipidemic, anti-obesity, anti-oxidant and anti-inflammatory agent. The study included 4 groups of rats: control group (group I), high fat diet–induced obesity rats (group II), alloxan-induced diabetic rats (group III) and carrageenin– induced inflammation in rats (group IV). The ginger was administered orally in a dose of about 500 mg/Kg body weight for 8 weeks. Serum was analyzed for contents of blood glucose, cholesterol, triglyceride, LDL-cholesterol, HLD-cholesterol, nitric oxide, lipid peroxide, prostaglandin E2 and C-reactive protein. Results: The high fat diet-induced obesity rats group treated with ginger showed significant reduction in body weight (p<0.0001). Both high fat diet –induced obesity rats group and alloxan-induced diabetic rats group treated with ginger showed significant reduction in serum levels of glucose, cholesterol, triglyceride and LDL-cholesterol and significant increase in serum level of HDL-cholesterol (p<0.0001 for each). In addition, there was significant reduction in the serum levels of nitric oxide and lipid peroxide (p<0.0001 for each). Finally carrageenin-induced inflammation in rats group treated with ginger showed significant reduction in serum levels of prostaglandin E2 and C-reactive protein (p<0.0001 for each). In conclusion: The results indicate that ginger has potential beneficial effects in conditions of obesity, diabetic dyslipidemia and could be considered as supplementary herbal therapy for prevention or treatment of obesity and diabetes. It protects tissues from lipid per-oxidations and inflammation and might be a promising candidate in prevention and or therapy for inflammation. | ||||
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