Serum Levels of Tumor Necrosis Factor-alpha, Nitric oxide and Malondialdehyde in Patients with Behcet’s Disease | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 1, Volume 28, Issue 2, December 2008, Page 1-8 PDF (167.91 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2008.37007 | ||||
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| Authors | ||||
| Mona Abdel Hamid* 1; Nadia Kashmiry2; Mohamed Marzouk3 | ||||
| 1Medical Biochemistry Department, Research Institute of Ophthalmology | ||||
| 2Clinical and Chemical Pathology Department, Research Institute of Ophthalmology | ||||
| 3Ophthalmology Department, Research Institute of Ophthalmology | ||||
| Abstract | ||||
| Objective:To determine the serum levels of tumour necrosis factor-alpha (TNF), nitric oxide (NO) and Malondialdehyde (MDA) in patients with Behcet’s disease (BD). This study included 27 patients with Behcet's disease and 16 healthy control subjects. Serum (TNF-) was measured by an enzyme linked immunosorbent assay (ELISA) while serum NO oxide levels were determined by Griess reaction. The MDA levels were detected by thiobarbituric acidreaction. There was a significant increase in the levels of TNF-, NO and MDA in Behcet's disease patients compared to controls. No significant correlation was detected between TNF-and NO or MDA levels in patients or controls. A significantpositive correlation was detected between serum levels of NO and MDA in BD patients.This suggests that elevated levels of TNF-, NO and MDA may be related to the pathogenesis of Behcet's disease. | ||||
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