Role of Taurine, Oxygen Therapy and their Mixture as Anti-cancer Agents on the N-nitrosodiethylamine (NED) Induced Cancer in Male Adult Rats | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 4, Volume 28, Issue 2, December 2008, Page 45-60 PDF (201.68 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2008.37024 | ||||
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| Authors | ||||
| Mohamed Heibashy* 1; Walaa El-Nahrawy2 | ||||
| 1Department of Biological Application, Nuclear Research Center, Atomic Energy Authority | ||||
| 2Zoology Department, Women's Collage, Ain Shams University | ||||
| Abstract | ||||
| The present investigation was conducted to elucidate the effects of taurine or oxygen molecules (Aquagen) or their mixture as anticancer agents in rats which were injected with N-nitrosodiethylamine (NED) in the presence of phenobarbital to promote cancer induction. As a result ofcancer induction, serum tumor markers [Carcino-embryonic antigen (CEA), alpha-fetoprotein (AFP) and cancer antigen 19.9 (CA19.9)] were significantly elevated. On the other hand, glutathione (GSH) content and glutathione peroxidase (GpX) activity were decreased significantly in blood, liver, stomach and intestine. Liver superoxide dismutase (SOD), catalase (CAT) and cytochrome P450activities were also decreased inthe cancer group of rats in comparison to the control group. The administration of taurine or oxygen molecules (Aquagen) improved all these alterations and the maximum ameliorating effects were exhibited in the rats treated with the mixture of the anti-oxidant agents. The results of this worke suggested that taurine or oxygen molecules (Aquagen) has an appreciable anti-cancer efficacy. | ||||
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