PGT-A: Yes versus No | ||||
| Journal of Reproductive Medicine and Embryology | ||||
| Article 2, Volume 1, Issue 2, July 2024, Page 74-86 PDF (360.23 K) | ||||
| Document Type: Debate | ||||
| DOI: 10.21608/jrme.2024.307483.1016 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Hisham Saleh  1, 2, 3; Nehal Adel 3, 4
| ||||
| 1Obstetrics and Gynecology Department, Faculty of Medicine, Alexandria University, Egypt. Egypt. | ||||
| 2Agial Fertility Center, Agial Hospital, Alexandria, Egypt. | ||||
| 3Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt. | ||||
| 4Madina ICSI Fertility Center, Madina women's hospital, Alexandria, Egypt. | ||||
| Abstract | ||||
| The goal of In Vitro Fertilisation is a healthy full-term fetus. Still ART remains inefficient. The selection of embryos for transfer is based mainly on morphology. Morphology alone cannot select the embryo with the highest implantation potential. About 60% of early human embryos are aneuploid, and it increases dramatically with increasing maternal age.Embryo aneuploidy is the leading cause of implantation failure and miscarriage after IVF. Aneuploidy screening through taking a biopsy from the morphologically normal embryos & analysis of the embryo DNA allows to deselect embryos with abnormal chromosomal number. Aneuploid embryos are unable to self-correct. The proposed benefit is to improve embryo selection over morphological assessment to enhance the likelihood that a transferred embryo would result in a healthy live birth. Despite its worldwide use, PGT-A has faced many challenges and concerns from opponents regarding its value, accuracy, validity, cost effectiveness. Several fundamental questions must be answered in this regard. | ||||
| Keywords | ||||
| PGT-A; Aneuploidy; Euploid; Pros; Cons | ||||
|
Statistics Article View: 371 PDF Download: 353 |
||||
