The potential protective antidiabetic effect of inosine in type 1 diabetic mice | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 7, Volume 27, Issue 1, June 2007, Page 95-108 PDF (163.09 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2007.37120 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Saad El-Sekelly* 1; Salah El-Din El-Sayed2 | ||||
| 1Department of Biochemistry , Faculty of Medicine El-Minia University | ||||
| 2Department of Physiology, Faculty of Medicine El-Minia University | ||||
| Abstract | ||||
| Inosine –a naturally occurring purine- was long considered to be an inactive metabolite of adenosine. However, recently inosine has been shown to be an immuno-modulator and anti-inflammatory agent. The aim of the present study was to determine whether inosine can affect the development of type 1 diabetes in mice. Type 1 diabetes was induced chemically by multiple low doses of streptozotocin. (MLDS). Mice were treated with inosine (100 or 200mg/kg/day) and diabetes incidence was monitored. The effect of inosine on oxidative stress also was determined. The results showed that inosine reduced the incidence of diabetes in streptozotocin-induced diabetes and also decreased the oxidative stress. The purine exerts anti-inflammatory effects in the pancreas, which is its likely mode of action. The use of inosine should be considered as a potential preventive therapy in humans susceptible to develop Type 1 diabetes. | ||||
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