Angiogenesis Versus Antiangiogenesis in Colorectal Cancer Patients with and Without Liver Metastases | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 10, Volume 27, Issue 1, June 2007, Page 133-150 PDF (179.73 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2007.37126 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Aisha Eid* 1; Moustafa EL-Shazli2; Alia Ayad3; Eman Zaki4 | ||||
| 1Department of Medical Biochemistr, Faculty of Medicine , Cairo University. | ||||
| 2Department of Surgery ,Faculty of Medicine , Cairo University. | ||||
| 3Department of Internal Medicine, Faculty of Medicine, Cairo University. | ||||
| 4Department of Radiology, National Cancer Institute, Cairo University. | ||||
| Abstract | ||||
| Angiogenesis is essential for tumor growth and progression and is mediated by positive and negative regulators of vessel growth. Since angiogenic mediators found in patient's serum have been postulated to reflect the angiogenic potential of a malignant tumor, the angiogenic stimulators activity such as vascular endothelial growth factor (VEGF) and angiogenesis inhibitors such as endostatin have been evaluated in the serum of patients with colorectal caner (CRC) with and without liver metastases, in an attempt to study the prognostic value of the above parameters. The present work was conducted on thirty six patients with colorectal cancer and twelve control subjects. The patients' group included twenty localized colorectal cancer patients all of them had radical surgical resection. The second patients' group consisted of sixteen colorectal cancer patients with liver metastases. The serum endostatin and VEGF levels weresignificantly higher in the patients with colorectal cancer versus healthy controls. When compared according to tumor stage, the liver metastatic group had significantly higher levels of serum endostatin and VEGF versus the localized invasive group (without distant metastasis). Both groups of patients with localized invasive cancer and patients with liver metastasis had significantly higher mean serum endostatin and VEGF levels versus healthy controls. Serum endostatin and VEGF levels inlocalized invasive group decreased significantly after resection of the tumor. There was a significant positive correlation between preoperativeendostatin and VEGF levels inall cancer patients. High preoperative VEGF and endostatin levels were strongly associated with the tumor size, tumor grade, lymph node metastases and subsequent recurrence. Significant positive correlation was, also, detected between endostatin levels and number as well as volume of hepatic metastases.The previous results denote that serum levels of endostatin, and VEGF were elevated and positively correlated in patients with CRC. The elevation was associated with the stage of CRC, greater disease burden and subsequent recurrence. Thus, elevation ofserum levels of endostatin, and VEGF might be considered as indicators of tumor invasion and metastasis in the future. Thus, the present study demonstrates the prognostic utility of measuring angiogenic and antiangiogenic factors before resection of colorectal cancer. | ||||
| Keywords | ||||
| colorectal caner (CRC); vascular endothelial growth factor (VEGF); Endostatin; liver metastases | ||||
|
Statistics Article View: 74 PDF Download: 145 |
||||
