Anti-inflammatory and Anti-apoptotic Potentials of Apigenin against Liver Injury Induced by Ischemia-Reperfusion in Rats | ||||
| Bulletin of Faculty of Pharmacy, Cairo University | ||||
| Article 1, Volume 57, Issue 1, 2019, Page 46-54 PDF (686.08 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfpc.2019.13703.1040 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Dalia El-Tanbouly  ; hala Zaki; Rania Abdelsalam; Aya Zaki
| ||||
| Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt. | ||||
| Abstract | ||||
| Apigenin is a dietary flavonoid that exists copiously in several herbs and vegetables. It exhibits anti-inflammatory, anti-mutagenesis, anti-proliferative and antioxidant properties. The present work aimed to investigate some of mechanisms underlying protective potential of apigenin in hepatic ischemia-reperfusion injury. Rats were divided into four groups; sham-operated, sham-operated pretreated with apigenin (25 mg/kg, p.o.), ischemia/reperfusion (I/R) (30 min ischemia and 1 h reperfusion) and I/R pretreated with apigenin. Compared with I/R group, pretreatment with apigenin markedly reduced transaminases levels and ameliorated tissue histopathological changes. Apigenin significantly reduced high mobility group box 1 (HMGB1) expression and suppressed liver tumor necrosis factor- α (TNF-α), nuclear factor κB (NF-κB) and myeloperoxidase (MPO) activity. Moreover, apigenin restored reduced glutathione (GSH), decreased liver lipid peroxidation, and boosted glutathione peroxidase (GPx) activity in addition to attenuation of apoptosis by increasing Bcl-2/Bax ratio. It may thus be concluded that inhibition of HMGBI by apigenin plays a role towards its antioxidant, anti-inflammatory as well as anti-apoptotic properties which are involved in conferring its hepato-protective properties | ||||
| Keywords | ||||
| Apigenin; apoptosis; Inflammation; Ischemia/reperfusion; Liver | ||||
|
Statistics Article View: 1,110 PDF Download: 1,352 |
||||
