Effects of Organic and Inorganic Mercury on the Apoptosis of the Neural Tube Cells of Zebrafish Embryos (Danio rerio)
Hassan, S., Abbott, L., Moussa, E. (2017). Effects of Organic and Inorganic Mercury on the Apoptosis of the Neural Tube Cells of Zebrafish Embryos (Danio rerio). EKB Journal Management System, 10(1), 49-59. doi: 10.21608/jva.2017.37156
Said A. Hassan; L. C. Abbott; E. A. Moussa. "Effects of Organic and Inorganic Mercury on the Apoptosis of the Neural Tube Cells of Zebrafish Embryos (Danio rerio)". EKB Journal Management System, 10, 1, 2017, 49-59. doi: 10.21608/jva.2017.37156
Hassan, S., Abbott, L., Moussa, E. (2017). 'Effects of Organic and Inorganic Mercury on the Apoptosis of the Neural Tube Cells of Zebrafish Embryos (Danio rerio)', EKB Journal Management System, 10(1), pp. 49-59. doi: 10.21608/jva.2017.37156
Hassan, S., Abbott, L., Moussa, E. Effects of Organic and Inorganic Mercury on the Apoptosis of the Neural Tube Cells of Zebrafish Embryos (Danio rerio). EKB Journal Management System, 2017; 10(1): 49-59. doi: 10.21608/jva.2017.37156

Effects of Organic and Inorganic Mercury on the Apoptosis of the Neural Tube Cells of Zebrafish Embryos (Danio rerio)

Journal of Veterinary Anatomy
Article 5, Volume 10, Issue 1, 2017, Page 49-59  XML
Document Type: Original Article
DOI: 10.21608/jva.2017.37156
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Authors
Said A. Hassan1; L. C. Abbott2; E. A. Moussa3
1Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.
2Department of Veterinary Integrative Biosciences, College of Veterinary Medicine, Texas A&M University USA
3aDepartment of Anatomy and Embryology, Faculty of Veterinary Medicine, Suez Canal University
Abstract
Abstract
In this study, we tested the hypothe- sis that mercury-induced develop- mental toxicity was mediated via ec- topic occurrence of apoptosis during embryonic development. We em- ployed microscopy to acquire images of whole-mount staining of apoptotic cells in zebrafish embryo exposed to 5, 10, 50, 80, 100, 150 ppb me hg and 50, 100, 200, 300, 400, 500 ppb hg cl from 5 hours post fertilization (hpf) to 48hpf.
In mercury-treated embryos with var- ying degrees of gross developmental malformations, significantly higher numbers of apoptotic cells were de- tected with this method. In the de- generating neural tube of mercury treated embryos apoptotic cells were detected, while in the healthy neural tube of the untreated controls no apoptotic cells were found. The per- centages of apoptotic cells increased with the dose in both Me hg and Hg cl exposure. Exposure to mercury, therefore, induced ectopic apoptosis at 84 hpf.
Keywords
Keywords: mercury; apoptosis; Zebrafish embryos
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