GENOTOXIC EFFECT OF HOSTATHION IN MICE | ||||
| Veterinary Medical Journal (Giza) | ||||
| Volume 49, Issue 1, January 2001, Page 59-69 PDF (3.07 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/vmjg.2001.371862 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| I FARAG* 1; K ABDEL AZIZ1; M ZAHER2; H DARWISH1 | ||||
| 1Cell Biology Department, National Research Centre, Dokki, Cairo, Egypt | ||||
| 2Zoology Department, Faculty of Science, Cairo Univ., Egypt. | ||||
| Abstract | ||||
| The genotoxic potential of technical hostathion was studied in the in vivo mouse system. The test Parameters used were chromosomal aberrations Assay and mitotic index in bone marrow cells; and Meiotic chromosomal aberrations assay and Meiotic index in germinal cells. Three dose levels (2.8, 4.2 and 5.6 mg/kg. b.wt.) were used for 3 And 5 days subacute treatments after oral administrations. Chromosome aberrations were observed In bone marrow cells and in diakineses-metaphase I cells from the testes. The dose and time yield effects statistically analysed. The results demonstrated that hostathion induced a significant structural chromosomal damages in somatic and Germinal cells as well as peridiploidy of numerical aberrations in somatic cells which were dose- And time dependent at all dose levels. A dose dependent significant decrease was observed in Mitotic and meiotic indices of mice cells. It was Concluded that hostathion has genotoxic effects. Therefore, the use of this pesticide in our life Must be restricted. | ||||
|
Statistics Article View: 69 PDF Download: 32 |
||||
