Efficacy of Vaginal Progesterone and N-Acetylcystiene versus Vaginal Progesterone to Prevent Preterm Birth in Pregnant Women with History of Preterm Birth | ||||
International Journal of Medical Arts | ||||
Volume 6, Issue 7, July 2024, Page 4635-4641 PDF (1.66 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ijma.2024.229803.1779 | ||||
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Authors | ||||
Aisha Ashraf Mohamed Hosny Sharaf ![]() | ||||
1Department of Obstetrics and Gynecology, Suez General Hospital, Ministry of Health, Suez, Egypt | ||||
2Department of Obstetrics and Gynecology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt | ||||
Abstract | ||||
Background: Preterm birth is a leading cause of neonatal morbidity and mortality worldwide, especially in women with a history of preterm birth. Vaginal progesterone has been shown to reduce the risk of preterm birth in this population. Moreover, N-acetylcysteine, known for its antioxidant and anti-inflammatory properties, is being investigated as a potential adjunct therapy to further enhance the protective effects of progesterone. The aim of the work: The present study aimed to evaluate the efficacy of a combination of vaginal progesterone and N-acetylcysteine compared to vaginal progesterone alone in preventing preterm birth in pregnant women with a history of preterm delivery. Patients and Methods: A randomized controlled trial was conducted involving a total of 70 pregnant women with a history of preterm birth. Participants were divided into two groups: one receiving vaginal progesterone and N-acetylcysteine, and the other receiving vaginal progesterone alone. The primary outcome measure was the rate of preterm birth [<37 weeks gestation] in each group. Results: Preliminary results demonstrated a lower rate of preterm birth in the group receiving the combination therapy compared to those receiving progesterone alone, but without statistically significant difference [p = 0.212]. Conclusion: The combination of vaginal progesterone and N-acetyl-cysteine shows promising results in preventing preterm birth in pregnant women with a history of preterm delivery. Further research is warranted to confirm these findings and explore the underlying mechanisms of this combined therapy for better maternal and neonatal outcomes. | ||||
Keywords | ||||
Progesterone; Oxidative Stress; Premature Birth | ||||
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