Efficacy of Vaginal Progesterone and N-Acetylcystiene versus Vaginal Progesterone to Prevent Preterm Birth in Pregnant Women with History of Preterm Birth
Sharaf, A., Nasr, M., Abd Elrehim, E. (2024). Efficacy of Vaginal Progesterone and N-Acetylcystiene versus Vaginal Progesterone to Prevent Preterm Birth in Pregnant Women with History of Preterm Birth. EKB Journal Management System, 6(7), 4635-4641. doi: 10.21608/ijma.2024.229803.1779
Aisha Ashraf Mohamed Hosny Sharaf; Mohammed Galal Nasr; Eman Ibrahim Abd Elrehim. "Efficacy of Vaginal Progesterone and N-Acetylcystiene versus Vaginal Progesterone to Prevent Preterm Birth in Pregnant Women with History of Preterm Birth". EKB Journal Management System, 6, 7, 2024, 4635-4641. doi: 10.21608/ijma.2024.229803.1779
Sharaf, A., Nasr, M., Abd Elrehim, E. (2024). 'Efficacy of Vaginal Progesterone and N-Acetylcystiene versus Vaginal Progesterone to Prevent Preterm Birth in Pregnant Women with History of Preterm Birth', EKB Journal Management System, 6(7), pp. 4635-4641. doi: 10.21608/ijma.2024.229803.1779
Sharaf, A., Nasr, M., Abd Elrehim, E. Efficacy of Vaginal Progesterone and N-Acetylcystiene versus Vaginal Progesterone to Prevent Preterm Birth in Pregnant Women with History of Preterm Birth. EKB Journal Management System, 2024; 6(7): 4635-4641. doi: 10.21608/ijma.2024.229803.1779

Efficacy of Vaginal Progesterone and N-Acetylcystiene versus Vaginal Progesterone to Prevent Preterm Birth in Pregnant Women with History of Preterm Birth

International Journal of Medical Arts
Volume 6, Issue 7, July 2024, Page 4635-4641  XML PDF (1.66 MB)
Document Type: Original Article
DOI: 10.21608/ijma.2024.229803.1779
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Authors
Aisha Ashraf Mohamed Hosny Sharaf email 1; Mohammed Galal Nasr2; Eman Ibrahim Abd Elrehim2
1Department of Obstetrics and Gynecology, Suez General Hospital, Ministry of Health, Suez, Egypt
2Department of Obstetrics and Gynecology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt
Abstract
Background: Preterm birth is a leading cause of neonatal morbidity and mortality worldwide, especially in women with a history of preterm birth. Vaginal progesterone has been shown to reduce the risk of preterm birth in this population. Moreover, N-acetylcysteine, known for its antioxidant and anti-inflammatory properties, is being investigated as a potential adjunct therapy to further enhance the protective effects of progesterone.
The aim of the work: The present study aimed to evaluate the efficacy of a combination of vaginal progesterone and N-acetylcysteine compared to vaginal progesterone alone in preventing preterm birth in pregnant women with a history of preterm delivery.  
Patients and Methods: A randomized controlled trial was conducted involving a total of 70 pregnant women with a history of preterm birth. Participants were divided into two groups: one receiving vaginal progesterone and N-acetylcysteine, and the other receiving vaginal progesterone alone. The primary outcome measure was the rate of preterm birth [<37 weeks gestation] in each group.
Results: Preliminary results demonstrated a lower rate of preterm birth in the group receiving the combination therapy compared to those receiving progesterone alone, but without statistically significant difference [p = 0.212].
Conclusion: The combination of vaginal progesterone and N-acetyl-cysteine shows promising results in preventing preterm birth in pregnant women with a history of preterm delivery. Further research is warranted to confirm these findings and explore the underlying mechanisms of this combined therapy for better maternal and neonatal outcomes.
Keywords
Progesterone; Oxidative Stress; Premature Birth
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