Risk Factors in Ischemic Heart Disease: Comparison between Disturbance in Serum Lipid Profile and Total Homocysteine in Old Myocardial Infarction
Abd-Elmoaty, M., Bogdady, A., Attia, M., Abo-Dahab, L., Kassem, A. (2007). Risk Factors in Ischemic Heart Disease: Comparison between Disturbance in Serum Lipid Profile and Total Homocysteine in Old Myocardial Infarction. EKB Journal Management System, 27(2), 63-72. doi: 10.21608/besps.2007.37297
Mohamed Abd-Elmoaty; Ahmed Bogdady; Mervat Attia; Lotfy Abo-Dahab; Ali Kassem. "Risk Factors in Ischemic Heart Disease: Comparison between Disturbance in Serum Lipid Profile and Total Homocysteine in Old Myocardial Infarction". EKB Journal Management System, 27, 2, 2007, 63-72. doi: 10.21608/besps.2007.37297
Abd-Elmoaty, M., Bogdady, A., Attia, M., Abo-Dahab, L., Kassem, A. (2007). 'Risk Factors in Ischemic Heart Disease: Comparison between Disturbance in Serum Lipid Profile and Total Homocysteine in Old Myocardial Infarction', EKB Journal Management System, 27(2), pp. 63-72. doi: 10.21608/besps.2007.37297
Abd-Elmoaty, M., Bogdady, A., Attia, M., Abo-Dahab, L., Kassem, A. Risk Factors in Ischemic Heart Disease: Comparison between Disturbance in Serum Lipid Profile and Total Homocysteine in Old Myocardial Infarction. EKB Journal Management System, 2007; 27(2): 63-72. doi: 10.21608/besps.2007.37297

Risk Factors in Ischemic Heart Disease: Comparison between Disturbance in Serum Lipid Profile and Total Homocysteine in Old Myocardial Infarction

Bulletin of Egyptian Society for Physiological Sciences
Article 5, Volume 27, Issue 2, December 2007, Page 63-72  XML PDF (139.18 K)
Document Type: Original Article
DOI: 10.21608/besps.2007.37297
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Authors
Mohamed Abd-Elmoaty* 1; Ahmed Bogdady2; Mervat Attia2; Lotfy Abo-Dahab2; Ali Kassem2
1Department of Biochemistry, Sohag Faculty of Medicine, Sohag University
2Department of Internal Medicine, Sohag Faculty of Medicine, Sohag University
Abstract
Objectives: Disturbance in the Low-density lipoprotein cholesterol (LDL-C), High-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), triglyceride (TG) and
serum total homocysteine are predisposing factors in myocardial infarction.Design
and methods: The study group consisted of 56 patients 35 male (aged 47.8±4.8
years), and 21 females (aged 46±4.3 years). The entry criterion for the patient group
has a history of typical or atypical chest pain, unequivocal changes in the
electrocardiogram. The control group consisted of 30 normal volunteers, 16 male
(aged 48.4±5.2 years) and 14 females (aged 45.1±4.9 years). Measurement of serum
total homocysteine was performed by enzyme linked immune sorbant assay (ELISA).
Measurement of TC, TG, and HDL-C were performed using spectrophotometer. LDL-C
was calculated.Results: Patients with myocardial infarction were found to have
higher serum total homocysteine levels (23.93±2.99 mol/L in male and 25.82±3.82
mol/L in female) than controls (10.45±2.73 mol/L and 12.92±0.9 mol/L in both
male and female respectively) (for each comparison; p < 0.001). Serum total
homocysteine levels were significantly correlated with high Triglycerides and low
HDL-C.Conclusions: The above mentioned findings suggest the potential usefulness of
Triglycerides, HDL-C and serum total homocysteine as risk factors in myocardial
infarction patients. These findings shouldbe used in the future studies on the etiology
and pathogenesis of myocardial infarction and toascertain which patients are at risk
for subsequent cardiovascular events and who will benefit from revascularization.
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