PROGNOSTIC SIGNIFICANCE OF BCL-2, BAX AND P53 EXPRESSION IN BREAST CANCER | ||||
| The Egyptian Journal of Surgery | ||||
| Volume 25, Issue 4, October 2006, Page 213-220 PDF (346.62 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejsur.2006.372985 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Abdel Azeem Ali* 1; Ali Alattar2; Maha Amin2 | ||||
| 1General Surgery Department, Al-Mansoura Faculty of Medicine, Egypt | ||||
| 2Pathology Department, Al-Mansoura Faculty of Medicine, Egypt | ||||
| Abstract | ||||
| Aim: of this study was to investigate the significance of apoptosis-related genes bcl-2 and Bax in breast carcinoma cases treated with radical surgery plus radiotherapy and adjuvant chemotherapy for at least 1 year and their relation with expression of p53. Methods: After surgical resection immunohistochemistry was performed to determine Bcl-2, Bax, p53 and estrogen receptor (ER) expression in paraffin-embedded tissues of 50 invasive breast cancers.And overall survival was assessed. Results: Bcl-2, Bax, P53 and ER immunostaining displayed a positive relation with increasing histologic grade (P=0.000) and negative relation with the staging .Bcl2 displayed a negative relation with p53 (P=0.035) and a positive relation with Bax and ER (P= 0.003 and P= 0.011 respectively). Expression of Bcl2 was associated significant improvement in overall survival (p=o.o1). Conclusion: regulation of apoptosis is important in invasive ductal carcinoma. These results indicate that bcl-2 expression is significantly associated with hormonal receptor status so it is good prognostic marker, and that p53 is a significant prognostic marker. No significant relation between Bax and overall survival in relation to the stage, p53 or ER. | ||||
| Keywords | ||||
| Carcinoma; Apoptosis; Prognosis | ||||
|
Statistics Article View: 48 PDF Download: 25 |
||||
