Serum glucose potassium ratio compared to theophylline level as a predictor of severity and outcome in acute theophylline toxicity | ||||
| Zagazig Journal of Forensic Medicine and Toxicology | ||||
| Article 9, Volume 22, Issue 2, July 2024, Page 160-178 PDF (546.29 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zjfm.2024.292199.1189 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
sarah elmorsy 1; Hassan hany2; Enas Abo Elwafa El-Taftazani3; Sarah Atef Eweda  4
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| 1forensic medicine and clinical toxicology department,faculty of medicine , Ain Shams university,Cairo ,Egypt clinical toxicology department,Armed forces college of medicine ,Cairo,Egypt | ||||
| 2Clinical toxicology department,armed forces college of medicine, Cairo,Egypt | ||||
| 3Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Ain Shams University Clinical toxicology department, Armed Forces College of Medicine | ||||
| 4forensic medicine and clinical toxicology department,faculty of medicine,Ain shams university,Cairo,Egypt | ||||
| Abstract | ||||
| Background: Acute theophylline toxicity represents a significant hazard, mainly in developing countries, due to its severe consequences, the absence of an antidote, and the existence of many factors that affect the prognosis of acutely theophylline-intoxicated patients. Aim: This study aimed to investigate the role of glucose/potassium ratio in the early prediction of the severity and outcome of acute theophylline toxicity in terms of morbidity and mortality, compared to serum theophylline concentration as the gold standard predictor. Methods: This cross-sectional study was conducted on adult patients with a diagnosis of acute theophylline toxicity admitted to the Poison Control Center, Ain Shams University hospitals, during the period from the beginning of January 2021 to the end of June 2022. For each patient, sociodemographic, clinical, and laboratory data, including theophylline levels and glucose/potassium ratio, were recorded. Results: Fifty-seven patients were enrolled in the study and classified according to the Poisoning Severity Score into minor, moderate, and severe toxicity groups. Both theophylline levels and glucose/potassium ratios were significantly higher in the severe and moderate groups compared to the minor group, and both predicted severe cases. However, theophylline level was more specific, while the glucose/potassium ratio was more sensitive for predicting severe cases. Conclusion: A high glucose/potassium ratio can be used for the early prediction of severe cases of acute theophylline toxicity | ||||
| Keywords | ||||
| Glucose /potassium ratio; theophylline level; theophylline toxicity; poison severity score; hemodialysis | ||||
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