A Comparative Study on the Effect of Leptin Hormone and Gemfibrozil in an Experimental Model of Hyperlipidemia Induced byChronic Ethanol Treatment | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 9, Volume 27, Issue 2, December 2007, Page 115-134 PDF (683.49 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2007.37311 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Heba Taha* 1; El-Sharkawi F1; Samy Abd El-Azim2 | ||||
| 1Biochemistry Department, Faculty of Pharmacy, Helwan University | ||||
| 2Biochemistry Department, Faculty of Pharmacy, Cairo University | ||||
| Abstract | ||||
| The aim of the present study was to evaluate the effect of leptin hormone and Gemfibrozil on the body weight, hepatic & serum lipids and lipoproteins profile in ethanol-induced hyperlipidemia in rats. The study was carried on 53 male albino rats weighing 130-160 g classified into six groups (from A-F). Three of these groups were fed a normal diet (A, C and D), while the other groups (B, E and F) were fed a normal diet combined with ethanol (6.32 g/kg body weight per oral) for the first 30 days. Subsequently, the first three groups received a normal diet for group (A), in addition to Gemfibrozil (100 mg/kg per oraldaily) for group (C) or exogenous leptin (230 µg/kg body weight, i.p.) every alternate day for group (D), while Groups (E) and (F) were administered Gemfibrozil and leptin respectively for the next 15 days. At the end of the total experimental period of 45 days, liver total lipids, serum concentrations of total cholesterol, HDL-C, LDL-C, VLDL-C, triglycerides, total proteins, albumin and glucose were measured. Ethanol-induced hyperlipidemia in rats resulted in marked increase of liver total lipids and significantincrease of serum total cholesterol, LDL-C, VLDL-C and triglycerides levels. This was associated with concomitant decrease in serum HDL-cholesterol and glucose levels as well as serum total proteins and albumin levels. However, no changes were observed in the body weight gain. Administration of leptin or Gemfibrozil separately or after ethanol-induced hyperlipidemia to rats was able to antagonize the ethanol-induced biochemical changes in the tissues studied. The results of the current study showed that leptin administered alone to rats resulted in marked decrease of their body weight and fasting serum glucose levels while serum HDL-C was elevated. These findings indicated that the chronic administration of exogenous leptin was more effective as compared to Gemfibrozil in preventing the rise in lipids and lipoproteins concentration in an animal model of alcohol-induced hyperlipidemia. | ||||
| Keywords | ||||
| Alcohol; leptin; Gemfibrozil; hyperlipidemia; Lipoproteins; proteins | ||||
|
Statistics Article View: 114 PDF Download: 149 |
||||
