Could Hematological parameters reflect inflammatory and nutritional state among dialysis patient?

Abdelmoneem, Shimaa; Arafa, Ayman Fathy; shoieb, Maha Elsaeed Abbas; Easa, Manal Mohamed; Metwally, Elsayed Anany

doi:10.21608/zumj.2024.310741.3509

	Could Hematological parameters reflect inflammatory and nutritional state among dialysis patient?
Zagazig University Medical Journal
Article 43, Volume 30, Issue 7, October 2024, Page 3644-3655 PDF (723.32 K)
Document Type: Review Articles
DOI: 10.21608/zumj.2024.310741.3509
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Authors
Shimaa Abdelmoneem¹; Ayman Fathy Arafa²; Maha Elsaeed Abbas shoieb ³; Manal Mohamed Easa ⁴; Elsayed Anany Metwally ⁵
¹lecturer of Internal medicine, Clinical Hematology Unit, Faculty of Medicine,Zagazig University
²Professor of Internal medicine,Clinical Hematology Unit, Faculty of Medicine, Zagazig University
³Resident of internal medicine, Damas Central Hospital
⁴lecturer of Clinical pathology, Faculty of Medicine, Zagazig University
⁵lecturer of Internal medicine, Clinical Hematology Unit, Faculty of Medicine, Zagazig University
Abstract
Background: When kidney function is consistently impaired, as in the case of chronic kidney disease (CKD) or chronic renal failure (CRF) or, diagnostic criteria include an unusually high blood creatinine level for longer than 3 months or the glomerular filtration rate (GFR) to be below 60 ml/min / 1.73 m2. Loss of energy stores and body proteins is one indicator of a worsening nutritional condition in patients with poorly controlled chronic renal disease, especially in its latter stages. Cases who had end-stage kidney disease (ESKD) are already fragile due to muscular atrophy, sarcopenia, and cachexia; furthermore, malnutrition is a powerful predictor of illness and death in this population. We intended to provide an outline of hematological parameters that could reflect inflammatory and nutritional state in dialysis patient. Conclusion: Cytokines like interleukin-6 (IL-6), interleukin-1 (IL-1), or tumor necrosis factor (TNF), gastric mediators like ghrelin as well as leptin, and adipokines may all play a role in mediating the anorexic process. More research into the identification and prevention of malnutrition, in particular, is necessary due to the complicated interaction between inflammatory and nutritional parameters during chronic kidney disease (CKD). We require additional studies on these mediators
Keywords
Hematological parameters; inflammatory; nutritional state; dialysis


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