Antioxidant and Antidiabetic t ceffE of Quercetin in rats | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 15, Volume 27, Issue 2, December 2007, Page 221-232 PDF (213.44 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2007.37369 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Mohamed Abdelmoaty* 1; Mohamed Ibrahim2; Nagwa Ahmed1; Mohamed Abdelaziz3 | ||||
| 1Department of Biochemistry, Sohag Faculty of Medicine, Sohag University | ||||
| 2Department of Pharmaceutics, El-Azhar Faculty of Pharmacy, El-Azhar University (Assiut) | ||||
| 3Department of Biochemistry, El-Azhar Faculty of Pharmacy, El-Azhar University (Assiut) | ||||
| Abstract | ||||
| Quercetin (QE), one of natural flavonoid group, was widely distributed as a secondary metabolite in plant k ingdom and recognized as anti-inflammatory, antiallergic, antiviral, antibacterial and antitumor activity. It has been believed that oxidative stress plays a role in the pathogenesis of diabetes mellitus (DM). The aim of the present study was the evaluation of possible effects of QE on blood glucose and antioxidant enzymes in experimental streptozotocin (STZ)-induced diabetes in rats. STZ was injected intraperitoneally at a single dose of 50 mg k g .-1 for diabetes induction. QE (15 mg k g .-1 day, intraperitoneal (i.p.) injection) was injected for 3 days prior to STZ administration; these injections were continued to the end of the study (for 25days).Glucose tolerance test and random plasma glucose were done for all animals. In order to determine the changes of cellular antioxidant defense system, antioxidant enzymes such as glutathione peroxidase (GSHPx), superoxide dismutase (SOD) and catalase (CAT) activities were measured in pancreatic homogenates. Quercetin had no effect on plasma glucose level of normal animals but its pre-treatment was able to prevent diabetes induced by single i p injection of streptozocin-treated rats. Antioxidant enzyme activity significantly decreased (P < 0.05) in STZ induced diabetic group. QE treatment significantly increased the antioxidant enzyme activities (P<0.05). It could be concluded that quercetin, a flavonoid with antioxidant properties, exerting its beneficial antidiabetic effects. However, it may be of little value in normoglycemic animals. | ||||
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