Prognostic Potential of BCL-2 and FOXP3 Expression in Bladder Carcinoma | ||||
SECI Oncology Journal | ||||
Volume 12, Issue 3, July 2024, Page 249-256 | ||||
View on SCiNiTO | ||||
Abstract | ||||
Background: bladder cancer develops and spreads due to a combination of environmental and inherited causes. Many biomarkers that are useful in determining the behavior and prognostic features of the tumour have been studied. Bcl-2 overexpression was linked to reduced tumour sensitivity to chemo- and radiation. FOXP3 has multiple roles in tumoural–immune system interactions, debates over FOXP3's function in immunological responses and carcinogenesis at various sites have emerged. Aim of the study: to detect Bcl-2 & tumoral FOXP3 immunohistochemical expression in urothelial carcinoma and its correlation with other clinicopathological data as well as disease free survival (DFS) and overall survival (OS). Methods: sixty cases of urothelial carcinoma had full clinical and follow-up data. Bcl-2 & tumoral FOXP3 immunohistochemical expression in urothelial carcinoma cases were investigated. Results: Positive Bcl-2 expression was detected in 41.7% of the studied urothelial carcinoma cases, while two thirds of cases showed positive FOXP3 expression. A statistically significant association between loss of Bcl-2 expression and high grade, advanced T stage, the presence of lymph node metastasis and lympho-vascular invasion (p=0.000) was detected. A statistically significant association between positive FOXP3 expression and both positive lymph node metastasis and lympho-vascular invasion was detected (p= 0.02 and p= 0.007 respectively). No significant association between Bcl-2 expression and DFS as well as OS, meanwhile, a statistically significant association between positive FOXP3 expression and short DFS as well as OS. Conclusion: The identification of patients with poor prognostic characteristics in urothelial bladder cancer who may be candidates for cancer therapy could be facilitated by loss of Bcl-2 expression and positive tumoral FOXP3 expression. | ||||
Keywords | ||||
Bladder cancer; Immunohistochemistry; Bcl-2; Tumoral FOXP3 | ||||
Supplementary Files
|
||||
Statistics Article View: 22 |
||||